Process for preparing prostaglandin analogs using organozirconiu

Details Process for preparing prostaglandin analogs using organozirconiu Process for preparing prostaglandin analogs using organozirconiu

1990-04-17

1991-10-08

Shaver, Paul F.

Organic compounds -- part of the class 532-570 series

Organic compounds

Silicon containing

556441, 549 4, 549214, 560121, 560122, 562503, 562504, C07F 718, C07C 6974, C07C 6106, C07C 6120

Patent

active

050556045

ABSTRACT:
A process for preparing a prostaglandin derivative by reacting an alkyne with zirconocene chloride hydride to produce a zirconium intermediate which is reacted with an alkyllithium and a first copper reagent selected from R.sup.2 Cu(CN)Li or the mixture CuCN and R.sup.2 Li to produce a higher order cuprate complex intermediate and reacting the higher order cuprate complex intermediate with a cyclopentenone to produce the prostaglandin derivative.

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Schwartz, Jeffrey, Transition Metal Hydride Reagents for Organic etc., J. Organomet. Chem. Library, 1, 461-488, 01/76.

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