Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1985-01-24
1988-07-26
Brown, J. R.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 18, 514886, 514887, 514936, 424140, A61K 3714
Patent
active
047600519
ABSTRACT:
A method of enhancing the wound-healing process in animals utilizing glycyl-1-histidyl-1-lysine: copper(II) (GHL-Cu) is disclosed. GHL-Cu functions as a superoxide dismutase which detoxifies tissue-damaging oxygen radicals, but does not evoke an antigenic response. A method of treating inflammatory conditions in animals and a method of reducing the traumatic effects in animals occurring subsequent to major tissue damage utilizing GHL-Cu is also disclosed.
REFERENCES:
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patent: 4440788 (1984-04-01), Terayama et al.
Raju et al., "Ceruloplasmin, Copper Ions, and Angiogenesis38 , JNCI 69:1183-1188, 1982.
Pickart, "The Biological Effects and Mechanism of Action of the Plasma Tripeptide Glycyl-1-Histidyl-1-Lysine, Lymphokines 8:425-446, 1983.
Poole and Zetter, "Stimulation of Rat Peritoneal Mast Cell Migration by Tumor-Derived Peptides, Cancer Research 43: 5857-5861, 1983.
Freedman et al., "Structure of the Glycyl-1-Histidyl-1-Lysine: Copper(II) Complex in Solution", Biochemistry 21:4540-4544, 1982.
Kwa et al., "PMR Studies of Ca(II) and Zn(II)--Interaction with GHL and Related Peptides", Peptides: Structure and Function 8:805-808, 1983.
Perkins et al., "The Structure of a Copper Complex of the Growth Factor GHL at 1.1 Resolution", Inorganica Chimica Acta 82:93-99, 1984.
Kwa, "GHL: Synthesis of Analogs and NMR Studies", Thesis, 1983.
Loker, "Synthesis of Blood Serum Peptide Cell Growth Factors", Thesis, 1980.
Chem. Abstracts Citation of Pickart et al. 93:1155m 1980.
Chem. Abstracts Citation of Williams et al. vol. 94:25451b 1981.
Pickart, Nature vol. 288, pp. 715-717 1980.
Mochida Pharmaceutical Co Ltd., cited in Chem. Abstracts vol. 94:145386f 1981.
Brown J. R.
Stone Jacqueline M.
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