Process for preparing thromboxane A.sub.2 antagonists

Details Process for preparing thromboxane A.sub.2 antagonists Process for preparing thromboxane A.sub.2 antagonists

1988-12-13

1991-10-08

Richter, Johann

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546257, 546258, 546261, 546264, 546265, 546269, 546267, 546270, 546285, 546291, 546293, 546294, 546295, 546296, 546297, 546300, 546305, 546306, 546307, 546308, 546309, 546311, 546312, 546331, 546332, 546333, 546334, 546335, 546337, 560 9, 560 10, 560 20, 560 21, 560 22, 560 23, 560 12, 560 13, 560 35, 562426, 562427, 562429, 562430, 562434, 562435, 562437, 562438, 562439, 562440, 564 17, 564 26, 564 27, 564 47, 564 48, 564 49, 564 50, 564 51, 564 52, 564 53, 564 54, 564 56, 564 57, 564102, 564154, 564161,

Patent

active

050555820

ABSTRACT:
This invention relates to a process for preparing useful thromboxane A.sub.2 inhibiting (.+-.)7-[3.alpha.-[1-[[(phenylamino)thioxomethyl]hydrazono]ethyl]-1.alpha. ,4.alpha.-bicyclo[2.2.1]hept-2.beta.-yl]-heptenoic acids and useful derivatives thereof from (.+-.)octahydro-1.alpha.-methyl-3a.alpha.,7a.alpha.-4.alpha.,7.alpha.-meth ano-2H-inden-2-ones.

REFERENCES:
patent: 4368332 (1983-01-01), Jones et al.
patent: 4416896 (1983-11-01), Nakane et al.
patent: 4430345 (1984-02-01), Jones
patent: 4438136 (1984-03-01), Jones et al.
patent: 4456617 (1984-06-01), Nakane et al.
patent: 4458091 (1984-07-01), Jones et al.
patent: 4596823 (1986-06-01), Jones et al.
Hiemstra et al., Tetrahedron Letters, No. 25, pp. 2183-2187 (1977).
Lemiere et al., J. Am. Chem. Soc. vol. 109, No. 5, pp. 1363-1370 (1987).
Piattner et al., J. Am. Chem. Soc., vol. 93, No. 7, pp. 1758-1761 (1970).
McMurry et al., Tetrahedron Letters, vol. 24, No. 10, pp. 979-982 (1983).
McMurry et al., Tetrahedron Letters, vol. 21, pp. 4313-4316 (1980).
Armstrong et al., "Competitive Antagonism at Thromboxane Receptors . . . ", Br. J. Pharmac. (1985) 84, 595-607.
Wilson et al., "Prostaglandin Endoperoxide . . . ", Advances in Pros., Throm. & Leukotriene Research vol. 14, 1985, pp. 393-425.
Nakane et al., "Aza-Substituted . . . ", Advances in Pros., Throm. & Leukotriene Research, 1985, vol. 15, 291.
Sprague et al., "Stereocontrolled Synthesis of . . . ", Advances in Pros., Throm. & Leukotriene Research, 1980, vol. 6, pp. 493-496.

Affiliated with

Also associated with

Rating

Process for preparing thromboxane A.sub.2 antagonists does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for preparing thromboxane A.sub.2 antagonists, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for preparing thromboxane A.sub.2 antagonists will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-257919