Ultrapurification of factor IX and other vitamin K-dependent pro

Details Ultrapurification of factor IX and other vitamin K-dependent pro Ultrapurification of factor IX and other vitamin K-dependent pro

1988-11-23

1991-10-08

Schain, Howard E.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

530380, 530384, 530413, 530830, 435183, 435184, C07K 320, C07K 328

Patent

active

050555570

ABSTRACT:
A method of recovering active, highly purified and concentrated vitamin K-dependent proteins from plasma, concentrate or mixtures of proteins produced by recombinant DNA technology using an immuno adsorbent comprising a monoclonal antibody.

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J. Biol. Chem., 255:4980-4983 (1980), Brown et al.
J. Biol. Chem., 253:5946-5951 (1978), Osterud et al.
Methods in Enzymology, 80:221-228 (1982), Miletich et al.
Goodall et al, "Affinity Depletion and Affinity Purification of Human Factor IX by Monoclonal Antibodies", Protides of the Biological Fluids, Proceedings of the 13th Colloquium, vol. 30, Feb. 1983, pp. 403-407, Pergamon Press, Oxford (Great Britain).
Vehar et al., Nature, 312, 337-342 (1984).
Proteins, Creighton, W. H. Freeman Co., New York (1983), 78-79.
F. Rotblat et al., "Preparation of Factor IX-Deficient Human Plasma . . . ", Thrombosis and Haemostasis, 46, (1) 1-478 (Jul. 12, 1981) (Abstract No. 1055, p. 339).
A. Goodall et al., "Preparation of Factor IX Deficient Human Plasma . . . ", Blood, vol. 59, No. 3 (Mar. 1982), pp. 664-670.

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