Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1997-01-31
2000-05-16
Feisee, Lila
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
4353201, 435325, 530350, 536 235, 536 2431, C12N 1512, C07K 14435, C07K 14705
Patent
active
060635940
ABSTRACT:
The present invention provides a novel anion channel (NANCH) and polynucleotides which identify and encode NANCH. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding NANCH and a method for producing NANCH. The invention also provides for agonists, antibodies, or antagonists specifically binding NANCH, and their use, in the prevention and treatment of diseases associated with expression of NANCH. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding NANCH for the treatment of diseases associated with the expression of NANCH. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding NANCH.
REFERENCES:
Greger, R., "Chloride Transport in Thick Ascending Limb, Distal Convolution, and Collecting Duct" Annu. Rev. Physiol. 50:111-122 (1988).
Barnard, E.A. et al., "Molecular biology of the GABA.sub.A receptor: the receptor/channel superfamily" Trends Neurosci. 16:502-509 (1987).
Riordan, JR et al., "Identification of the Cystic Fibrosis Geme: Cloning and Characterization of Complementary DNA" Science 245:1066-1073 (1989).
Landry, D et al., "Molecular Cloning and Characterization of p64, a Chloride Channel Protein from Kidney Microsomes" J. Biol. Chem. 268:14948-14955 (1993) (GI 289404).
Landry, DW et al., "Purification and Reconstitution of Chloride Channels from Kidney and Trachea" Science 244:1469-1472 (1989).
Redhead, CR et al., "A ubiquitous 64-kDa protein is a component of a chloride channel of plasma and intracellular membranes" Proc. Natl. Acad. Sci. 89:3716-3720 (1992).
Borsani, G, (GI 895845) GenBank Sequence Database (Accession 895845), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894.
Borsani, G, (GI 895844) GenBank Sequence Database (Accession X87689), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894.
Howell, S et al., "Identification and characterisation of a homologue of p64 in rat tissues" FEBS Letter 390:207-210 (1996).
Bandman Olga
Goli Surya K.
Feisee Lila
Incyte Pharmaceuticals Inc.
Pak Michael
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