Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Cosmetic – antiperspirant – dentifrice
Reexamination Certificate
1999-03-05
2001-10-02
Williamson, Michael A. (Department: 1616)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Cosmetic, antiperspirant, dentifrice
C424S195110, C514S559000, C514S740000
Reexamination Certificate
active
06296859
ABSTRACT:
FIELD OF THE INVENTION
The present invention relates to a novel cosmetic composition for compounds with a lipoamino acid structure and with calmant activity.
BACKGROUND OF THE INVENTION
In modern life, skin is attacked by various factors outside the human body; these are, in particular, atmospheric pollution, ultraviolet radiation, either of natural or artificial nature, or other stresses such as mechanical or chemical stresses.
On account of the ever-increasing occurrence of these problems, in particular in highly urbanized areas, skin protection has become a predominant aspect of the search for novel cosmetic products. In response to attack or to sensations of attack on the skin, the concept of a calmant cosmetic product has been developed.
According to European Economic Community counsel directive No. 76/768/EEC of Jul. 27, 1976 modified by directive No. 93/35/EEC of Jun. 14, 1993, the term “cosmetic product” refers to any substance or preparation intended to be placed in contact with the various surface parts of the human body (epidermis, pilous and hair system, nails, lips and genital organs) or with the teeth and the oral mucosae in order, exclusively or mainly, to clean them, fragrance them, modify their appearance and/or correct body odours and/or protect them or keep them in good condition.
In general, the term “calmant product or calmant cosmetic formulation” refers to any product in formulation which gives a sensation of well-being of the skin, whether this is, in particular, a sensation of softness, of elasticity and/or of comfort experienced by the individual by applying the product to his or her skin.
The Applicant has discovered that all of these stresses on the skin induce a pre-inflammatory state.
During this state, various events occur, in particular the production of free radicals and the synthesis of various pro-inflammatory enzymes, such as elastase. These two phenomena (production of free radicals and of elastase) will not only maintain and propagate this state of inflammation, but will also have harmful consequences on the skin. The production of free radicals, for example, is responsible for the death of many cells, on account of the deleterious effects induced in particular in primordial molecules such as DNA, lipids or proteins; as for elastase, it degrades elastin, the main protein in dermal support. These two phenomena will thus reflect the events which occur during an inflammation, as well as the harmful effects on the skin resulting therefrom.
The Applicant has thus sought to develop a composition which is effective, on the one hand, against the cutaneous stress caused by external attacking factors on the skin, in particular against the harmful effects caused by enzymes which maintain and develop the inflammatory process, and, on the other hand, by inhibiting the process for the production of free radicals.
Compounds of lipoamino acid structure, such as, for example, those described in the international patent applications published under Nos. WO 92/20647, WO 92/21318, WO 94/26694 and WO 94/27561 are, on account of their amphiphilic structure, biological vectors which are particularly advantageous as regulators of skin physiology and prove to be suitable for a large number of applications, in particular in cosmetics.
SUMMARY OF THE INVENTION
Now, the Applicant has found that compositions comprising, as active principles, a combination of lipoamino acids with certain natural extracts of plants, have both anti-free-radical activity and anti-elastase activity. The Applicant has also found that this activity is the result of the synergism between these two families of active principles.
One subject of the invention is a composition characterized in that it comprises, as active principle, at least one compound of formula (I):
or its topically acceptable salts, in which R represents the characterizing chain of a saturated or unsaturated, linear or branched fatty acid containing from 3 to 30 carbon atoms, R
1
represents the characterizing chain of an amino acid and m is between 1 and 5,
and the constituents of at least one extract and/or of at least one tincture from plants of the Nympheacea family.
The expression “topically acceptable salt” refers to any salt of the acid of formula (I) which is biologically acceptable for the skin and/or the mucosae, i.e. any salt which can, in particular, adjust the pH of the composition to a value of between 3 and 8 and preferably approximately equal to 5, i.e. to a pH in the region of the skin's pH. These may be, in particular, alkali metal salts such as the sodium, potassium or lithium salts, alkaline-earth metal salts such as the calcium, magnesium or strontium salts; they may also be metal salts such as the divalent zinc or manganese salts or alternatively the trivalent iron, lanthanum, cerium or aluminum salts.
The compound of formula (I) present in the composition which is the subject of the present invention can be in free acid form or in partially or totally salified form.
The expression “characterizing chain” used in the context of the present patent application denotes the main non-functional chain of the fatty acid or of the amino acid under consideration.
Thus, for a fatty acid corresponding to the general formula R—COOH, the characterizing chain will be the chain represented by R. The radical R represents in particular a radical containing from 5 to 22 carbon atoms chosen from the pentyl, hexyl, heptyl, octyl, nonyl, decyl, undecyl, dodecyl, tridecyl, tetradecyl, pentadecyl, hexadecyl, heptadecyl, octadecyl, nonadecyl, eicosyl, uneicosyl, docosyl, heptadecenyl, eicosenyl, uneicosenyl, docosenyl or heptadecadienyl or decenyl radicals. The invention relates more particularly to the composition as described above for which, in formula (I), the fragment R—CO contains from 7 to 22 carbon atoms and represents in particular one of the following radicals: hexanoyl, heptanoyl, octanoyl (capryloyl), decanoyl (caproyl), undecylenoyl, dodecanoyl (lauroyl), tetradecanoyl (myristyl), hexadecanoyl (palmitoyl), octadecanoyl (stearyl), eicosanoyl (arachidoyl), docosanoyl (behenoyl), octadecenoyl (oleyl), eicosenoyl (gadoloyl), docosenoyl (erucyl), octadecadienoyl (linolenoyl). In a first preferred variant of the present invention, in formula (I), the fragment R—CO (I) contains from 14 to 18 carbon atoms.
For an amino acid represented by the general formula
H
2
N—CHR
1
—COOH,
as for an amino acid represented by the formula:
the characterizing chain will be the chain represented by R
1
. R
1
represents in particular the characterizing chain of one of the amino acids chosen from glycine, alanine, serine, aspartic acid, glutamic acid, valine, threonine, arginine, lysine, proline, leucine, phenylalanine, isoleucine, histidine, tyrosine, tryptophan, asparagine, cysteine, cystine, methionine, hydroxyproline, hydroxylysine and ornithine.
The invention relates more particularly to the composition as described above for which, in formula (I), R
1
represents the characterizing chain of proline.
The expression “at least one compound of formula (I)” means that the composition according to the invention can contain one or more of these compounds.
In the definition of the composition which is the subject of the present invention, the words “extract” and “tincture” are used in their respective senses as established in the 1997 edition of the European Pharmacopoeia; extracts are concentrated preparations of liquid, solid or intermediate consistency, generally obtained from dried plant or animal starting materials. Tinctures are preparations generally obtained from dried plant or animal starting materials.
The expression “extracts or tinctures from plants of the Nympheacea family” denotes in particular the extracts or tinctures of water lily, such as “
Nuphar japonicum
”, of lotus, such as “
Nelumbo nucifera
” or of “
Brasenia purpurea
”. These extracts or tinctures are commercially available. Some are listed in the French and/or European Pharmacopoeias. The invention relates more particularly to the composition as described abo
Societe d'Exploitation de Produits pour les Industries Chim
Williamson Michael A.
Young & Thompson
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