Preparation of .alpha.-6-deoxytetracyclines

Details Preparation of .alpha.-6-deoxytetracyclines Preparation of .alpha.-6-deoxytetracyclines

1975-10-22

1977-01-04

Davis, C.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07C10319

Patent

active

040013219

ABSTRACT:
Hydrogenation of a mixture prepared from a 6-deoxy-6-demethyl-6-methylenetetracycline compound, and a catalytic amount of a dicarboxylato(triphenylphosphine)rhodium(II) or dicarboxylato(substituted triphenylphosphine)rhodium(II) compound, in a reaction-inert solvent, produces the corresponding 6-deoxytetracycline compound. The hydrogenation takes place with a stereoselectivity which favors the 6.alpha.-isomer over the 6.beta.-isomer. The products are known antibacterial agents.

REFERENCES:
patent: 3165551 (1965-01-01), Blackwood et al.
patent: 3200149 (1965-08-01), Blackwood et al.
patent: 3794671 (1974-02-01), Wilkinson

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