6-Substituted 2-naphthyl acetic acid derivatives

Details 6-Substituted 2-naphthyl acetic acid derivatives 6-Substituted 2-naphthyl acetic acid derivatives

1975-03-17

1977-01-04

Mars, Howard T.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

26029351, 2602948C, 26050111, 26050114, 424308, 424320, C07C 6976

Patent

active

040013014

ABSTRACT:
2-Naphthyl acetic acid derivatives and the corresponding amides, esters, hydroxamic acids and addition salts thereof, optionally substituted at the .alpha.-position on the acetic acid moiety and/or at position 6 and/or at positions 1, 4, 7 or 8 on the naphthyl ring and optionally saturated at positions 3 and 4, are anti-inflammatory, analgesic, antipyretic and anti-pruritic agents. A pharmaceutical method of effecting treatment of inflammation, pain, pyrexia and pruritus by the administration of naphthyl acetic acid derivatives. A pharmaceutical composition for use in the treatment of the above maladies comprising a naphthyl acetic acid derivative.

REFERENCES:
patent: 3385886 (1968-05-01), Nicholson et el.
patent: 3452079 (1969-06-01), Shen et al.
patent: 3506671 (1970-04-01), Kaiser et al.
patent: 3562336 (1971-02-01), Nelson
Horeau et al., "Chem Abs" 42, (1948). 7282a.
Buu Hoi et al., J. Chem Soc 485-489 (1953).
Khorana et al., Indian J. of Pharmacy, vol. 23, 297-301, 1961.
Ormancy et al., Bull Chem Soc 962-969 (1955).
Horeau, Bull Chem Soc, No. 149, 711-716 (1948).
Fried et al., Chem Abs 74 (1971) 3436k, 3438n.
Fried et al., Chem Abs 73 (1970), 120417v.
Fried et al., Chem Abs 71 (1971) 91161h.

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