Method for producing nitroguanidine derivatives

Details Method for producing nitroguanidine derivatives Method for producing nitroguanidine derivatives

1999-12-08

2001-06-26

Raymond, Richard L. (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

C544S215000, C546S290000, C548S182000, C549S492000, C564S230000

Reexamination Certificate

active

06252072

ABSTRACT:

The invention relates to a process for the preparation of a compound of formula
wherein
R
1
is hydrogen or C
1
-C
4
-alkyl;
R
2
is hydrogen, C
1
-C
6
-alkyl, C
3
-C
6
-cycloalkyl or a radical —CH
2
B;
A is an aromatic or non-aromatic, monocyclic or bicyclic heterocyclic radical which is unsubstituted or—depending on the substitution possibilities of the ring system—mono- to penta-substituted by substituents selected from the group comprising halogen, C
1
-C
3
-alkyl, C
1
-C
3
-alkoxy, halogen-C
1
-C
3
-alkyl, C
1
-
3
-halogenalkoxy, cyclopropyl, halogencyclopropyl, C
2
-C
3
-alkenyl, C
2
-C
3
-alkynyl, C
2
-C
3
-halogenalkenyl and C
2
-C
3
-halogenalkynyl, C
1
-C
3
-alkylthio, C
1
-C
3
-halogenalkylthio, allyloxy, propargyloxy, allylthio, propargylthio, halogenallyloxy, halogenallylthio, cyano and nitro; and
B is phenyl, 3-pyridyl or thiazolyl, which are optionally substituted by one to three substituents from the group comprising C
1
-C
3
-alkyl, C
1
-C
3
-halogenalkyl, cyclopropyl, halogencyclopropyl, C
2
-C
3
-alkenyl, C2-C
3
-alkynyl, C
1
-C
3
-alkoxy, C
2
-C
3
-halogenalkenyl, C
2
-C
3
-halogenalkynyl, C
1
-C
3
-halogenalkoxy, C
1
-C
3
-alkylthio, C
1
-C
3
-halogenalkylthio, allyloxy, propargyloxy, allylthio, propargylthio, halogenallyloxy, halogenallylthio, halogen, cyano and nitro; and, if appropriate, the possible E/Z isomers, E/Z isomeric mixtures and/or tautomers thereof, each in free form or in salt form;
by hydrolysis of a compound of formula
wherein R
1
, R
2
and A have the same significances as given for formula (I), and
R
3
signifies unsubstituted or substituted C
1
-C
10
-alkyl, C
3
-C
6
-cycloalkyl, phenyl or benzyl; characterised in that the reaction is carried out at a pH value of between 7 and 14.
The compounds of formula (I) may be present as E/Z isomers, e.g. in the following two isomeric forms
Accordingly, any reference to compounds of formula (I) hereinafter is understood to include also their corresponding E/Z isomers, even if the latter are not specifically mentioned in each case.
The compounds of formula (I) may be present partly in the form of tautomers, for example in the forms
Accordingly, any reference to compounds of formula (I) hereinbefore and hereinafter is understood to include also their corresponding tautomers, even if the latter are not specifically mentioned in each case.
The compounds of formula (I) and, where appropriate, the E/Z isomers and tautomers thereof, may be present as salts. Compounds of formula (I) having at least one basic centre may form e.g. acid addition salts. These are formed for example with strong inorganic acids, typically mineral acids, e.g. sulphuric acid, a phosphoric acid or a hydrohalic acid, or with strong organic carboxylic acids, typically C
1
-C
4
alkanecarboxylic acids substituted where appropriate for example by halogen, e.g. acetic acid, such as dicarboxylic acids that are unsaturated where necessary, e.g. oxalic, malonic, maleic, fumaric or phthalic acid, typically hydroxycarboxylic acids, e.g. ascorbic, lactic, malic, tartaric or citric acid, or benzoic acid, or with organic sulphonic acids, typically C
1
-C
4
alkane- or arylsulphonic acids substituted where appropriate for example by halogen, e.g. methanesulphonic or &rgr;-toluenesulphonic acid. Salt of compounds of formula (I) with acids of the said kind are preferably obtained when working up the reaction mixtures.
In a broader sense, compounds of formula (I) with at least one acid group can form salts with bases. Suitable salts with bases are for example metal salts, typically alkali or alkaline earth metal salts, e.g. sodium, potassium or magnesium salts, or salts with ammonia or an organic amine, such as morpholine, piperidine, pyrrolidine, a mono-, di- or tri-lower alkylamine, e.g. ethyl-, diethyl-, triethyl- or dimethylpropylamine, or a mono-, di- or trihydroxy-lower alkylamine, e.g. mono-, di- or triethanolamine. Corresponding internal salts where appropriate may also be formed. Preferred compounds within the scope of this invention are agrochemically advantageous salts. Hereinbefore and hereinafter, the free compounds of formula (I) and their salts are understood where appropriate to include also by analogy the corresponding salts or free compounds of formula (I). The same applies to E/Z isomers and tautomers of compounds of formula (I) and salts thereof. The free form is preferred.
In the definition of the above formulae (I) and (II), the individual generic terms are to be understood as follows:
The halogen atoms considered as substituents may be both fluorine and chlorine, and bromine and iodine, whereby fluorine, chlorine and bromine are preferred, especially chlorine. Halogen in this context is understood to be an independent substituent or part of a substituent, such as in halogenalkyl, halogenalkylthio, halogenalkoxy, halogencycloalkyl, halogenalkenyl, halogenalkynyl, halogenallyloxy or halogenallylthio. The alkyl, alkylthio, alkenyl, alkynyl and alkoxy radicals considered as substituents may be straight-chained or branched. Examples of such alkyls which may be mentioned are methyl, ethyl, propyl, isopropyl, butyl, isobutyl, sec.-butyl or tert.-butyl. Suitable alkoxy radicals which may be mentioned are, inter alia: methoxy, ethoxy, propoxy, isopropoxy or butoxy and the isomers thereof. Alkylthio is for example methylthio, ethylthio, isopropylthio, propylthio or the isomeric butylthio. If the alkyl, alkoxy, alkenyl, alkynyl or cycloalkyl groups considered as substituents are substituted by halogen, they may be only partially halogenated or also perhalogenated. The above-mentioned definitions apply here to halogen, alkyl and alkoxy. Examples of the alkyl elements of these groups are methyl which is mono- to trisubstituted by fluorine, chlorine and/or bromine, such as CHF
2
or CF
3
; ethyl which is mono- to pentasubstituted by fluorine, chlorine and/or bromine, such as CH
2
CF
3
, CF
2
CF
3
, CF
2
CCl
3
, CF
2
CHCl
2
, CF
2
CHF
2
, CF
2
CFCl
2
, CF
2
CHBr
2
, CF
2
CHClF, CF
2
CHBrF or CClFCHClF; propyl or isopropyl, mono- to heptasubstituted by fluorine, chlorine and/or bromine, such as CH
2
CHBrCH
2
Br, CF
2
CHFCF
3
, CH
2
CF
2
CF
3
or CH(CF
3
)
2
; butyl or one of its isomers, mono- to nonasubstituted by fluorine, chlorine and/or bromine, such as CF(CF
3
)CHFCF
3
or CH
2
(CF
2
)
2
CF
3
; 2-chlorocyclopropyl or 2,2-difluorocyclopropyl; 2,2-difluorovinyl, 2,2-dichlorovinyl, 2-chloroalkyl, 2,3-dichlorovinyl or 2,3-dibromovinyl.
If the defined alkyl, alkoxy or cycloalkyl groups are substituted by other substituents, they may be mono- or repeatedly substituted by identical or different substituents from those listed. In the substituted groups, it is preferable for one or two further substituents to be present. The cycloalkyl radicals considered as substituents may be, for example, cyclopropyl, cyclobutyl, cyclopentyl or cyclohexyl. Alkenyl and alkynyl groups contain an unsaturated carbon-carbon bond. Typical representatives are allyl, methallyl or propargyl, but also vinyl and ethynyl. The double or triple bonds in allyloxy, propargyloxy, allylthio or propargylthio are separated from the linkage point to the hetero atom (O or S) preferably by a saturated carbon atom.
It is already known that, in order to produce 1,3-disubstituted 2-nitroguanidines, a further substituent may be introduced into monosubstituted 2-nitroguanidines (e.g. by alkylation) (see e.g. EP patent applications 0.375.907, 0.376.279 and 0.383.091). Owing to the presence of three reactive hydrogen atoms in the monosubstituted 2-nitroguanidines used as the starting material in these reactions, the previously proposed substitution reactions of this kind are often non-selective and lead to undesired substitution products. The mentioned EP patent applications describe the production of 1,3-disubstituted 2-nitroguanidines by reacting monosubstituted nitroisothioureas with primary amines whilst cleaving mercaptan. However, these nitroisothiourea compounds, containing alkylthio leaving groups, which are proposed as starting compounds in the known processes, can only be ob

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