Drug – bio-affecting and body treating compositions – Topical sun or radiation screening – or tanning preparations
Reexamination Certificate
2000-02-14
2001-06-26
Dodson, Shelley A. (Department: 1616)
Drug, bio-affecting and body treating compositions
Topical sun or radiation screening, or tanning preparations
C424S060000, C424S400000, C424S401000, C514S241000
Reexamination Certificate
active
06251373
ABSTRACT:
BACKGROUND OF THE INVENTION
1. Technical Field of the Invention
The present invention relates to novel cosmetic compositions for topical application, for the photoprotection of the skin and/or hair against ultraviolet radiation (such compositions hereinafter simply designated “antisun,” “sunscreen” or “photoprotective” compositions) and to the use of same for the cosmetic applications indicated above.
This invention more especially relates to the aforesaid sunscreen/cosmetic compositions comprising, formulated into a cosmetically acceptable vehicle, diluent or carrier therefor, a tripartite combination comprising (a) at least one specific benzotriazole compound, as a first screening agent, (b) at least one bisresorcinyltriazine compound, as a second screening agent, and (c), as a third screening agent, at least one compound containing at least two benzoazolyl functional groups or at least one compound containing at least one benzodiazolyl functional group, the said first, second and third screening agents being present in the subject compositions in proportions suitable for eliciting a synergistic effect with regard to the protection factors conferred.
2. Description of the Prior Art
It is known to this art that light radiation with wavelengths of from 280 nm to 400 nm promotes tanning of the human epidermis and that irradiation with wavelengths of from 280 to 320 nm, i.e., UV-B radiation, causes erythemas and skin burns which may be harmful to the development of natural tanning; this UV-B radiation must therefore be screened from the skin.
It is also known to this art that UV-A radiation, with wavelengths of from 320 to 400 nm, which causes tanning of the skin, can also adversely affect it, in particular in the case of sensitive skin or of skin continually exposed to solar radiation. UV-A rays cause, in particular, a loss in the elasticity of the skin and the appearance of wrinkles, resulting in premature aging. Such irradiation promotes the triggering of the erythemal reaction or accentuates this reaction in certain individuals and can even be the cause of phototoxic or photoallergic reactions. It is therefore desirable to also screen out UV-A radiation.
A wide variety of cosmetic compositions for the photoprotection (UV-A and/or UV-B) of human skin are known to this art.
These photoprotective/sunscreen compositions are typically emulsions of oil-in-water type (namely, a cosmetically acceptable vehicle, diluent or carrier comprising a continuous aqueous dispersing phase and a non-continuous oily dispersed phase) which contains, in various concentrations, one or more conventional lipophilic and/or hydrophilic organic screening agents capable of selectively absorbing harmful UV radiation. These screening agents (and their amounts) are selected according to the desired protection factor (the protection factor (PF) being expressed mathematically by the ratio of the irradiation time required to attain the erythemogenic threshold with the UV screening agent to the time required to attain the erythemogenic threshold without UV screening agent).
SUMMARY OF THE INVENTION
It has now surprisingly and unexpectedly been determined that the combination of three specific sunscreen compounds already per se known to this art provides synergistically active sunscreen compositions exhibiting markedly improved protection factors.
Briefly, the present invention features novel cosmetic compositions, in particular photoprotective/sunscreen compositions, comprising, in a cosmetically acceptable vehicle, diluent or carrier, (a) at least one specific benzotriazole compound, as a first screening agent, (b) at least one bisresorcinyltriazine compound, as a second screening agent, and (c), as a third screening agent, at least one compound containing at least two benzoazolyl functional groups and/or at least one compound containing at least one benzodiazolyl functional group, the said first, second and third screening agents advantageously being formulated into the subject compositions in a proportion eliciting a synergistic effect with regard to the sun protection factors conferred.
The present invention also features the use of the subject compositions in the production of cosmetic compositions suited for the protection of the skin and/or hair against the deleterious effects of ultraviolet radiation, in particular solar radiation.
This invention thus also features a cosmetic regime/regimen for the photoprotection of skin and/or hair against the damaging effects of ultraviolet radiation, in particular solar radiation, which essentially entails topically applying onto the skin/hair a photoprotecting amount of a composition in accordance herewith.
DETAILED DESCRIPTION OF BEST MODE AND SPECIFIC/PREFERRED EMBODIMENTS OF THE INVENTION
More particularly according to the present invention, novel cosmetic or dermatological compositions, in particular photoprotecting/sunscreen compositions, are provided which comprise, formulated into a cosmetically acceptable vehicle, diluent or carrier therefor:
(a) as a first screening agent, at least one benzotriazole compound having the structural formula (I):
in which A is a hydrogen atom or a divalent radical —L—W—; the radicals Y, which may be identical or different, are each a C
1
-C
10
alkyl radical, a halogen atom, a C
1
-C
10
alkoxy radical or a sulfo group, with the proviso that, in the latter case, two adjacent Y radicals on the same aromatic nucleus can together form an alkylidenedioxy group in which the alkylidene moiety has 1 or 2 carbon atoms, with the further proviso that the Y radicals are other than a sulfo group when A is other than a hydrogen atom; n has the value 1, 2 or 3; L is a divalent radical having the following formula (II):
in which X is O or NH; Z is a hydrogen atom or a C
1
-C
4
alkyl radical; n is an integer ranging from 0 to 3, inclusive; m is 0 or 1; p is an integer ranging from 1 to 10 inclusive; W is a radical having one of the following formulae (1), (2) or (3):
in which formulae the radicals R, which may be identical or different, are each a C
1
-C
10
alkyl, phenyl or 3,3,3-trifluoro-propyl radical, at least 80% by number of the R radicals being methyl radicals; the radicals B, which may be identical or different, are each an R radical or the V radical of the following formula:
in which Y, n and L are as defined above; r is an integer ranging from 0 to 50, inclusive, and s is an integer ranging from 1 to 20, inclusive, and, if s=0, at least one of the two B radicals is a radical V; u is an integer ranging from 1 to 6, inclusive, and t is an integer ranging from 0 to 10, inclusive, with the proviso that t+u is equal to or greater than 3;
(b) as a second screening agent, at least one bisresorcinyltriazine compound; and
(c) as the third screening agent, at least one compound containing at least two benzoazolyl functional groups per molecule or at least one compound containing, per molecule, at least one benzodiazolyl functional group, the said first, second and third screening agents being present in a proportion eliciting a synergistic effect with regard to the sun protection factors conferred.
By the term “containing at least two benzoazolyl functional groups” are intended, per molecule, at least two functional groups of the benzoxazolyl, benzothiazolyl or benzimidazolyl type.
By the term “containing at least one benzodiazolyl functional group” is intended, per molecule, a functional group of the benzodioxazolyl, benzodithiazolyl or benzodiimidazolyl type.
The benzotriazole compounds of formula (I) in accordance with the invention are screening agents already per se known to this art. They are described and prepared according to the syntheses illustrated in U.S. Pat. Nos. 4,316,033 and 4,328,346, and in EP-B-0,354,145, EP-B-0,392,883 and EP-B-0,660,701, hereby expressly incorporated by reference.
Exemplary nonsilicone compounds of formula (I) wherein A is a hydrogen atom include:
2-(2′-hydroxy-5′-methylphenyl)benzotriazole (n=1 and Y=CH
3
), such as the product marketed under the trademark Uva
Burns Doane Swecker & Mathis L.L.P.
Dodson Shelley A.
Societe L'Oreal S.A.
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