Process for preparing 3-chloro-6-(2-hydroxyphenyl)-pyridazines

Details Process for preparing 3-chloro-6-(2-hydroxyphenyl)-pyridazines Process for preparing 3-chloro-6-(2-hydroxyphenyl)-pyridazines

1980-09-02

1982-07-20

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

C07D23712

Patent

active

043407331

ABSTRACT:
A process for preparing 3-chloro-6-(2-hydroxyphenyl)pyridazines by the reaction of 6-(2-hydroxyphenyl)-3(2H)-pyridazinones with phosphorus oxychloride and a disubstituted formamide. The chloropyridazine compounds are useful intermediates for preparing compounds which have .beta.-adrenergic blocking and vasodilator activity and are useful as antihypertensive agents.

REFERENCES:
patent: 4053601 (1977-10-01), Coates et al.
patent: 4111935 (1978-09-01), Coates et al.
Derwent Abstract 30597B (Japanese 5 4032-489).
Aki et al., Chem. Pharm. Bull. 20(6):1325-1327 (1972).
Schulte et al., Angew. Chem. Intern. Edit. 4:1081-1082 (1965).
Kallury et al., Tetrahedron Letters No. 41, 3655-3658 (1977).

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