Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
1999-10-12
2001-06-19
Cook, Rebecca (Department: 1614)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S458000, C514S002600, C514S557000, C514S738000, C424S195110
Reexamination Certificate
active
06248763
ABSTRACT:
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates generally to compositions for treating various skin conditions and, more particularly to a topically applied skin treatment composition including a nicotinic ester as an active ingredient.
2. Brief Description of the Prior Art
Various compositions containing nicotinic esters have been known and commonly used for inducing and stimulating hair growth. Examples of these can be found in the U.S. patents to Grollier, U.S. Pat. Nos. 5,157,036 and 4,968,685. In U.S. Pat. No. 5,468,492, Szaloki discloses a use of vitamin E nicotinate as a rubefacient to improve the circulation of the blood of the scalp. Other compositions containing methyl nicotinate have been proposed as an analgesic for the symptomatic relief of localized pain of musculo-skeletal etiology, as evidenced by the U.S. patent to Fisher, U.S. Pat. No. 3,880,996.
A product is available and sold under the trade name FINALGON, which is a topical rubefacient including nicotinic acid. The product is intended for use as a temporary relief from pain caused by muscular rheumatism and does not disclose use as a skin treatment.
A variety of published articles describe the effects and uses of nicotinic acid, nicotinamide and methyl nicotinate (Murrell, T., “The Cutaneous Reaction to Nicotinic Acid,”
A.M.A. Archives of Dermatology,
79:545-552, May, 1959, Shalita, A. R., “Topical nicotinamide compared with clindamycin gel in the treatment of inflammatory acne vulgaris,”
International Journal of Dermatology,
34(6): 434-7, June, 1995, and Remme, J. J., “Bullous pemphigold successfully controlled by tetracycline and nicotinamide,”
British Journal of Dermatology,
133(1): 88-90, July, 1995). None of these articles describe a use of the particular compositions of nicotinamide, its derivatives, nicotinic acid, its esters, or their derivatives as presented by this invention.
In U.S. Pat. Nos. 3,729,685 and 3,906,108 Kligman and Felty, respectively, describe a method of acne treatment which involves topical application of vitamin A to the skin. This method does not, however, include the use of vitamin B3, nicotinic acid or any salt thereof for acne treatment. One disadvantage of using vitamin A in skin treatment is the substantial skin irritation vitamin A causes. This irritation makes such treatment unpleasant and may even lead to an individual foregoing treatment altogether. Although a cream formulation of vitamin A may reduce the undesirable side effects, it does not do so entirely. This leaves an individual who applies the vitamin A treatment with irritated, stinging and itching skin.
The prior art does not provide for the topical application of nicotinamide, its derivatives, nicotinic acid, and nicotinic esters or their derivatives in the compositions presented herein. The present invention presents a spectrum of unique and novel formulas by which nicotinamides, nicotinic acids and nicotinic esters may be topically applied to the skin. Some of the formulas embody an original compilation of ingredients which include skin moisturizers, emollients, vitamin E, carriers and other beneficial elements. Some formulas are designed to dry quickly and clearly upon application. These formulas provide the user with a smooth and even skin tone without the greasy, sticky finish or irritation caused by many other skin care products. Further, these formulas are effective in treating a variety of disorders and skin conditions, including the removal of blackheads.
SUMMARY OF THE INVENTION
The present invention relates to a discovery that a nicotinic ester and particularly the compound methyl nicotinate, is highly beneficial when topically applied to treat skin conditions. More particularly, when combined with a skin moisturizer, a suitable carrier, an emollient (e.g. glycerol or glycerin), vitamin E and other elements and excipients, methyl nicotinate, and nicotinic acid have surprising efficacy in treating various skin conditions including: acne blemishes; acne pimples, blackheads and whiteheads; psoriasis; seborrheic dermatitis, or dandruff; large pores, fine lines and age spots; stretch marks; cellulite; itching; pain and itching from insect bites and stings; fungi; varicose veins; flaking and scaly skin; burns (including sunburn); bedsores and black and blue marks.
In addition to those listed heretofore, minor amounts of other additives may optionally be present. This would include an ingredient effective in treating dermatophyte fungi.
The invention also encompasses a method of using the composition to treat various skin conditions or other disorders. This method generally includes patting the composition on one's palm or an applicator, such as a cosmetic pad or cotton. The composition is then topically applied to the skin or other affected area such as a fingernail or toenail. The application may also include, in the case of using the composition as a body or facial wash, applying the composition to one's skin then rinsing it away with water.
REFERENCES:
patent: 3729568 (1973-04-01), Kligman
patent: 3880996 (1975-04-01), Fisher
patent: 3906108 (1975-09-01), Felty
patent: 3912666 (1975-10-01), Spitzer et al.
patent: 4505896 (1985-03-01), Bernstein
patent: 4968685 (1990-11-01), Grollier
patent: 5157036 (1992-10-01), Groller
patent: 5240945 (1993-08-01), Warshaw
patent: 5468492 (1995-11-01), Szaolki et al.
patent: 2210789 A1 (1989-06-01), None
patent: 56964 A1 (1982-12-01), None
CA 115:166437, Fed. Regist. (1991), 56(159), 41008-20 Aug. 16, 1991, abstract.
Cook Rebecca
Oltman Flynn & Kubler
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