Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Reexamination Certificate
2000-05-11
2001-09-04
Scheiner, Laurie (Department: 1648)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
C435S070100, C435S360000
Reexamination Certificate
active
06284491
ABSTRACT:
The present invention is related generally to the isolation and characterization of new genes and proteins. More particularly, the present invention is related to providing isolated, substantially pure, biologically active human thyrotropin (hTSH) synthesized by a cloned gene.
Thyrotropin (TSH) is a pituitary peptide hormone which regulates important body functions. However, heretofore there was no stable, reliable and economic means of synthesizing this important hormone.
SUMMARY OF THE INVENTION
It is, therefore, an object of the present invention to provide biologically active, synthetic human thyrotropin in substantially pure, isolated form.
It is another object of the present invention to provide a cloned gene which directs the expression of biologically active human thyrotropin in a suitable vector.
It is a further object of the present invention to provide an assay kit for measuring thyroid-stimulating hormone as well as other thyrotropin substances such as thyroid-stimulating immunoglobulins and the like.
It is a further object of the present invention to provide a method of diagnosing and treating human thyroid cancer.
Other objects and. advantages will become evident from the following detailed description of the invention.
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Weintraub Bruce D.
Wondisford Fredric E
Knobbe Martens & Olson Bear LLP.
Scheiner Laurie
The United States of America as represented by the Department of
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