Synthetic resins or natural rubbers -- part of the class 520 ser – Synthetic resins – Compositions to be polymerized by wave energy wherein said...
Reexamination Certificate
1999-07-20
2001-03-13
Seidleck, James J. (Department: 1711)
Synthetic resins or natural rubbers -- part of the class 520 ser
Synthetic resins
Compositions to be polymerized by wave energy wherein said...
C522S044000, C522S030000, C522S047000, C522S120000, C522S121000, C264S001380, C264S002500, C264S002600, C264S001360, C264S002300, C264S001100, C623S006120, C623S006560, C623S006600
Reexamination Certificate
active
06201036
ABSTRACT:
FIELD OF THE INVENTION
The present invention relates to medicine, in particular, to ophthalmology, and more specifically to a light-curable polymer material, to a method for making an elastic intraocular lens and to an elastic intraocular lens.
BACKGROUND ART
At present intraocular lens made of polymethylmethacrylate are most widely used in ophthalmology.
Intraocular lenses of a polymer material are known (see, e.g., RF patent No. 2074673), which are made by curing a composition prepared from a mixture of oligourethanemethacrylate with the number of oxypropylene groups in the range of from 60 to 150, methylcarbitol methacrylate, methacrylic acid and 2,2-dimethoxy-2-phenylacetophenone, which are taken with the following weight % ratio of the components:
2,2-dimethoxy-2-phenylacetophenone
0.1-0.8
methacrylic acid
2.0-10.0
methylcarbitol methacrylate
20-40
oligourethanemethacrylate
balance.
A substantial disadvantage of the polymer material is expressed by the insufficient elasticity of an intraocular lens made therefrom. Intraocular lenses from polymethylmethacrylate feature good optical characteristics and low toxicity. A drawback of these lenses is their high rigidity and hence the possibility of postoperative complications due to injury to surrounding eye tissues.
A method is known for making elastic intraocular lenses by means of high-temperature vulcanization in a casting mold of a silicone-organic polymer with subsequent thermostatic control.
It should be indicated that a prolonged holding of virtually all known polymers at high temperatures around 200-300° C. results not only in their cross-linking, but also to destruction. As a result of polymer destruction, low-molecular products are formed which are capable of diffusing into the eye tissues and causing toxic effects.
Another drawback of this method is that only a very narrow range of materials can be used to make intraocular lenses, i.e. such materials in which the shrinkage factor is close to zero. This also relates to methods for making lens, wherein curing of liquid material in a casting mold occurs under the effect of light or some other radiation. Since the shrinkage factor of the overwhelming majority of light-curable materials lies with the range of from 5 to 22%, it is considered to be impossible to use this method to make lenses having acceptable optical characteristic (see, e.g., “Polymer optic materials,” Collection of papers, Chernogolovka, 1989,p. 199).
Known are U.S. Pat. No. 4,382,902 (1983) and No. 4,166,088 (1979), which teach a method for making eye contact lenses by curing a liquid material in a mold made from an optically transparent material under the effect of ultraviolet light. It should be noted that contact lenses are convexo-concave, and a considerable variation in thickness is not characteristic for such lenses. In view of this, it is conceivable that the damping devices provided in casting molds make it possible to attain satisfactory optical characteristics of the lenses.
Since an intraocular lens is biconvex or planoconvex, the variation in thickness is much greater than in contact lenses. Therefore, none of the casting mold constructions makes it possible to produce intraocular lenses having satisfactory optical characteristics, using the aforesaid method.
A method for making an elastic intraocular lens is known, wherein a liquid light-curable material is poured into a casting mold and annealing, i.e. irradiation, is carried out.
The produced intraocular lens also has insufficient elasticity, and this results in increased traumatism of the eye when an operation is performed.
It is often required that an intraocular lens have areas with more and less elasticity. A method for making intraocular lenses is known (see, e.g., RF patent No. 2074673). However, this method does not make it possible to make intraocular lenses having areas with different degrees of elasticity, either.
SUMMARY OF THE INVENTION
The object of the present invention is to create a light-curable polymer material in which the presence of a bifunctional component—oligocarbonatemethyacrylate and octylmethacrylate, makes it possible to reduce adhesion, enhance strength of the material, enhance its resilience and flexibility, and to make articles therefrom which may restore their shape after removal of a load.
Another object of the invention is to develop a method for making an elastic intraocular lens in which the use of a light-curable polymer material, including a bifunctional component—oligocarbonatemethacrylate, octylmethacrylate and an inhibitor of radical polmerization-2,4-ditretbutylortoquinone—makes it possible to make an elastic intraocular lens having reduced adhesion, enhanced strength, resilience, which is capable of being rolled into a tube and restoring its shape without deformation after the load is removed, and which also has smooth edges without roughness.
One more object of the invention is to create an elastic intraocular lens made of a light-curable polymer material including a bifunctional component—oligocarbonatemethacrylate, octylmethacrylate and an inhibitor of radical polymerization-2,4-ditretbutylortoquinone—and having reduced adhesion, enhanced strength, resilience, the capability of being rolled into a tube and restoring its shape without deformation after removal of the load, and also having smoother edges without roughness.
One more object of the invention is to create an elastic intraocular lens which combines in its construction elements having different elasticity, this making it possible to reduce traumatism of tissues during an operation.
On more object of the invention is to create an elastic intraocular lens which has high optical characteristics, no toxicity, which ensures a postoperative course without complications.
This object is achieved in that in accordance with the invention, the light-curable polymer material for making an intraocular lens is a mixture of components consisting of: oligourethanemethacrylate, having the structural formula
wherein: R is a radical having the formula
m is within the range of from 60 to 150,
octylmethacrylate, having the formula
oligocarbonatemethacrylate, having the formula
2,2-dimethoxy-2-phenylacetophenone
and 2,4-ditretbutylortoquinone
wherein the indicated components are taken in the following weight % ratios:
2,2-dimethoxy-2-phenylacetophenone
0.1-0.7
2,4-ditretbutylortoquinone
0.001-0.006
octylmethacrylate
8-42
oligocarbonatemethacrylate
2-8
oligourethanemethacrylate
balance.
The stated object is also achieved in that a method for making an elastic intraocular lens includes the followings steps:
using a casting mold having a base and a lid, said base and lid being made of optically transparent material, and having an annular spacer, a thickness of which is determined by the thickness of a haptic portion of the lens, said annular spacer being placed between said base and said lid,
filling said base with liquid light-curable material, the base having an area for forming an optic portion of the intraocular lens, an area for forming the haptic portion of the lens, areas covered with a layer of opaque material and limited by said annular spacer,
closing said base with the lid having areas covered with a layer of opaque material, an area for forming said optic portion of the intraocular lens, placed coaxially with said area for forming the optic portion of the lens on said base, by means of this forming a cell for curing said lens,
pressing said lid against said base, wherewith removing an excess of said light-curable material from the curing cell,
using a initial components of said light-curable material a mixture of components consisting of oligourethanemethacrylate having the structural formula
wherein: R is a radical having the formula
m is within the range of from 60 to 150,
octylmethacrylate, having the formula
oligocarbonatemethacrylate, having the formula
2,2-dimethoxy-2-phenylacetophenone
and 2,4-ditretbutylortoquinone
wherein the indicated components are taken in the following weight % ratios:
2,2-dimethoxy-2-phenylac
Fedorov Svyatoslav Nikolaevich
Karavaev Alexandr Alexandrovich
Linnik Leonid Feodosievich
Treushnikov Valery Mikhailovich
Viktorova Elena Alexandrovna
Ladas and Parry
McClendon Santa L.
Mezhoiraslevoi Nauchno-Tekhnichesky Komplex “Mikrokhirurgia Glaz
Seidleck James J.
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