Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1994-09-19
1998-07-28
Wax, Robert A.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
435 691, 435 915, 4351723, 4352523, 536 2372, C12N 1511, C12N 1512, C12N 1548, C12P 1934
Patent
active
057864640
ABSTRACT:
The invention features a synthetic gene encoding a protein normally expressed in mammalian cells wherein at least one non-preferred or less preferred codon in the natural gene encoding the mammalian protein has been replaced by a preferred codon encoding the same amino acid.
REFERENCES:
patent: 4652639 (1987-03-01), Stabinsky
patent: 5082767 (1992-01-01), Hatfield et al.
patent: 5270171 (1993-12-01), Cercek et al.
patent: 5276268 (1994-01-01), Strauch et al.
patent: 5405776 (1995-04-01), Kotewicz et al.
patent: 5464774 (1995-11-01), Baird et al.
Fortkamp, E., et al., DNA, vol. 5, No. 6, "Cloning and expression in Escherichia coli of a synthetic DNA for hirudin, the blood coagulation inhibitor in the leech", pp. 511-517, 1986.
Cohen, J., et al., "Expression of the HIV-1 env (gp160) in the yeast Saccharomyces cerevisiae via expression/secretion vectors and partial characterization of the gene product", in Modern Approaches, New Vaccines, pages 1988.
Chou, K.-C., et al., AIDS Research and Human Retroviruses, vol. 8, No. 12, "Diagrammatization of codon usage in 339 human immunodeficiency virus proteins and its biological implication", pp. 1967-1976, 1992.
Rangwala, S. H., et al., Gene, vol. 122, No. 2, "High-level production of active HIV-1 protease in Escherichia coli", pp. 263-269.
Scorer, C. A., et al., Gene, vol. 136, Nos. 1 & 2, "The intracellular production and secretion of HIV-1 envelope protein in the methylotrophic yeast Picha pastoris", pp. 111-119, 1993.
Holler, T. P., et al., Gene, vol. 136, Nos. 1 & 2, "HIV-1 integrase expressed in Escherichia coli from SyntheticC Gene", PP. 323-328 , 1993.
Bosch, M. L., et al., Journal of Virology, vol. 68, No. 11, "Insertion of N-linked glycosylation sites in the variable regions of the human immunodeficiency virus type-1 surface protein through AAT triplet reiteration", pp. 7566-7569, 1994.
van Hemert, F. J., et al., Journal of Molecular Evolution, vol. 41, No. 2, "The tendency of lentiviral open reading frames to become A-rich: Constraints imposed by viral genome organization and cellular tRNA availability", pp. 132-140, 1995.
Cohen, J., et al., (abstract), in Modern Approaches New Vaccines, "Expression of the HIV-1 env (gp160) in the yeast Saccaromyces cerevisiae via expression/secretion vectors and partial characterization of the gene product", 1988.
Cochrane et al., "Identification and Charaterization of Intragenic Sequences Which Repress Human Immunodeficiency Virus Structural Gene Expression", Journal of Virology, 65(10):5305-5314, (1991).
D'Agostino et al., "The Rev Protein of Human Immunodeficiency Virus Type 1 Promotes Polysomal Association and Translation of gag/pol and vpu/env mRNAs", Molucular and Cellular Biology, 12(3):1375-1386, (1992).
Feinberg et al., "HTLV-III Expression and Production Involve Complex Regulation at the Levels of Splicing and Translation of Viral RNA", Cell, 46:807-817, (1986).
Hammarskjold et al., "Regulation of Human Immunodeficiency Virus env Expression by the rev Gene Product"Journal of Virology, 63(5):1959-1966, (1989).
Nakamura et al., "Two types of linkage between codon usage and gene-expression levels", FEBS LETTERS, 289(1):123-125, (1991).
Robinson et al., "Codon usage can affect efficiency of translation of genes in Escherichia coli", Nucleic Acids Research, 12(17):6663-6671, (1984).
Zhang et al., "Low-usage codons in Escherichia coli, yeast, fruit fly and primates", Gene, 105(1):61-72 (1991).
Zhang et al., "Graphic Analysis of Codon Usage Strategy in 1490 Human Proteins", Journal of Protein Chemistry, 12(3):329-335, (1993).
Coulombe and Skup, Gene 46:89-95 (1986).
Kamiya et al., Jpn J. Cancer Res. 80:200-203 (1989).
McCarrey, Nucleic Acids Res. 18:949-955 (1990).
Newgard et al., Proc. Natl. Acad. Sci. USA 83:8132-8136 (1986).
Sharp et al., Nucleic Acids Res. 16:8207-8211 (1988).
Inouye et al., FEBS Letters 341:277-280 (1994).
Hernan et al., Biochemistry 31:861908628 (1992).
Williams et al., Nucleic Acids Research 16:10453-10467 (1988).
Moore William W.
The General Hospital Corporation
Wax Robert A.
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