Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1997-02-11
1998-10-20
Chang, Ceila
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
544129, 544361, 5142315, 514255, 514326, C07D40900
Patent
active
058246908
ABSTRACT:
The present invention relates to substituted pyrrolidinyl-3-yl-alkyl-piperidines, their stereoisomers, and pharmaceutically acceptable salts thereof and processes for preparation of the same. The compounds of the present invention are useful in their pharmacological activities such as tachykinin antagonism, especially substance P and neurokinin A antagonism, and the like. Compounds having the property of tachykinin antagonism are indicated for conditions associated with neurogenic inflammation and other diseases described herein.
REFERENCES:
patent: 5340822 (1994-08-01), Emonds-alts
patent: 5607947 (1997-03-01), Hipskind
Harrison et al. "High affinity selective neurokinin 2 and neurokinin 3 receptro antagonists from a common structural template" Gorden Conference Poster, 1996.
Chorev, et al., "Toward Nonpeptidal Substance P Mimetic Analogues: Design, Synthesis, and Biological Activity", Hebrew University of Jerusalem, 725-732, vol. 31 (1991).
Hagiwara, et al., Studies on Neurokinin Antagonists 3. , J. Med. Chem, 36, 2266-2278, 1993.
Kudlacz, et al., "In Vitro and in vivo characterization of MDL 105,212A, a nonpepetide NK-1/NK-2 tachykinin rectptor Antagonist", J. Pharm. & Exp. Ther., 277(2) 840-851 (1996).
Burkholder, et al., "Identification and chemical synthesis of MDL 105,212, a non-peptide tachykinin atnagonist with high affinity for NK1 and NK2 receptaors", Bioorganic & Med. Chem. Letters, 6(8), 951-956 (1996).
Kudlacz, et al., "The NK-1/NK-2 tachykinin receptor antagonist MDL 105,172A inhibits capsaicin-induced respiratory effects in guinea pigs", 8th Inter. Con., Inflammation Res. Assoc., 1996.
Burkholder, et al., "NK1/NK2 receptor antagonists", Tachykinins & their Antagonists Conference, 1996.
Burkholder, et al., "Identification and chemical synthesis of MDL 105212 a non-selective nonpeptide tachykinis receptor antagonist", Tachykinins '95 from Basic Science to Clinical Application Conference, 1995.
Burkholder Timothy P.
Kudlacz Elizabeth M.
Le Tieu-Bihn
Maynard George D.
Chang Ceila
Hoechst Marion Roussel Inc.
Stemerick David M.
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