Spiro-tricyclicaromatic succinimide derivatives

Details Spiro-tricyclicaromatic succinimide derivatives Spiro-tricyclicaromatic succinimide derivatives

1987-09-09

1989-09-05

Schwartz, Richard A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548147, 548216, 548308, 548411, C07D47110, C07D23376, C07D23378

Patent

active

048640280

ABSTRACT:
Disclosed are substituted or unsubstituted planar tricyclic fluorene or nuclear analogs thereof, spiro-coupled to a five-membered ring containing a secondary amide, and the pharmaceutically acceptable salts thereof. These compounds are useful, inter alia, in the treatment of diabetes. Also disclosed are processes for the preparation of such compounds; pharmaceutical compositions comprising such compounds; and methods of treatment comprising administering such compounds and compositions when indicated for, inter alia, long term, prophylactic treatment of the diabetes syndrome.

REFERENCES:
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patent: 4127665 (1978-11-01), Sarges et al.
patent: 4436745 (1984-03-01), York
patent: 4438272 (1984-03-01), York
patent: 4537982 (1985-08-01), York
M. Winstead et al, Journal of Medicinal Chemistry, vol. 19, No. 2, pp. 279-286, 1976.
H. Pan et al, Journal of Medicinal Chemistry, vol. 10, No. 1, pp. 957-959, 1967.
H. Pan et al, Journal of Medicinal Chemistry, vol. 7, pp. 31-38, 1964.

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