Treatment of hepatitis C virus infection using a protease...

Details Treatment of hepatitis C virus infection using a protease... Treatment of hepatitis C virus infection using a protease...

1999-02-05

2001-08-28

Wortman, Donna C. (Department: 1648)

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

C424S094650, C514S025000, C514S021800, C514S027000

Reexamination Certificate

active

06280728

ABSTRACT:

CROSS-REFERENCE TO RELATED APPLICATIONS
This application is entitled to priority pursuant to 35 U.S.C. §119 to German patent application 198 04 742.8, filed Feb. 6, 1998.
BACKGROUND OF THE INVENTION
The present invention relates to the use of at least one hydrolytic enzyme and at least one flavonoid for the treatment of diseases caused by hepatitis C viruses.
Hepatitis is an inflammation of the liver, which can arise on account of various causes. The acute forms of hepatitis are mostly caused by viruses. At present, six different types of hepatitis virus are known (A-E and G). Hepatitis C is a viral disease in which persistence of the hepatitis C virus or chronic hepatitis can ensue. This chronic hepatitis C develops in about 50% of the infected individuals. About 20% of the individuals suffering from chronic hepatitis C show histological signs of hepatic cirrhosis. In addition to this, hepatitis C virus probably plays an important part in the development of hepatocellular carcinomas. These complications often lead to death. The medicinal treatment of hepatitis C is still in the experimental stage. Usually, individuals suffering from chronic hepatitis C are treated by dietetic measures in order to spare the hepatic metabolism. The use of &agr;-interferon and ribavarin is also considered. However, these agents often show undesired side-effects, and moreover both are very expensive. Furthermore, both preparations show a lasting effect in only about 20% of the patients.
SUMMARY OF THE INVENTION
The present invention was therefore based on the technical problem of providing further substances or combinations which show an improved effect in the treatment of diseases caused by hepatitis C virus.
This task is achieved by the use of at least one hydrolytic enzyme and at least one flavonoid.


REFERENCES:
Kabil et al., Oral enzyme therapy in hepatitis C patients. International Journal of Tissue Reactions 19(1/2): 97-98, 1997.*
Stedman's Medical Dictionary, Williams & Wilkins, 1995.*
G. Stauder, et al., “Oral Enzyme Therapy In Hepatitis C Patients”, International Journal of Immunotherapy XIII(3/4) pp. 153-158 (1997)—published Mar. 1998.

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