Novel HMG-CoA reductase inhibitors

Details Novel HMG-CoA reductase inhibitors Novel HMG-CoA reductase inhibitors

1987-12-21

1989-09-05

Pal, Asok

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549292, 562469, A61K 31365, C07D30920

Patent

active

048639575

ABSTRACT:
Disclosed are novel 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors useful as antihypercholesterolemic agents represented by the formula ##STR1## and the corresponding ring-opened hydroxy acids derived therefrom and pharmaceutically acceptable salts thereof.
Pharmaceutical compositions containing said compounds and method of inhibiting the biosynthesis of cholesterol therewith are also disclosed.

REFERENCES:
patent: 4282155 (1981-08-01), Smith et al.
patent: 4308378 (1981-12-01), Stataker
patent: 4503072 (1985-03-01), Hoffman et al.
patent: 4622338 (1986-11-01), Baran et al.
patent: 4772626 (1988-09-01), Smith et al.

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