Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1987-04-09
1989-09-05
Sutto, Anton H.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514247, 514248, 514259, 514309, 514312, 514376, 514418, 544237, 544239, 544287, 546141, 546157, 546158, 546172, 548221, 548472, 548506, A61K 3140, C07D20946
Patent
active
048639486
ABSTRACT:
A series of novel alkanesulphonamidophenyl-N-alkyl-N-(heterocyclic-alkyl)alkylamine derivatives have been prepared, including their pharmaceutically acceptable salts, wherein the heterocyclic moiety is a 5- or 6-membered nitrogen-containing heterocyclic group which is attached to the adjacent carbon atom by a carbon or nitrogen atom and optionally contains a further heteroatom selected from oxygen and nitrogen, said nitrogen-containing heterocyclic group being either (i) substituted by a phenyl or benzyl group or (ii) fused at two adjacent carbon atoms to a benzene ring, with the resulting heterocyclic ring moiety also being optionally substituted. These particular compounds are useful in therapy as highly effective anti-arrhythmic agents and therefore, are of value in the treatment of various cardiac arrythmias. The most preferred member compound of the series is 2-hydroxy-2-(4-methanesulphonamidophenyl)-N-methyl-N-[2-(6-chloro-2H-isoin dolin-1-on-2-yl)ethyl]ethylamine. Methods for preparing all these compounds from known starting materials are provided.
REFERENCES:
patent: 3341584 (1967-09-01), Larsen et al.
patent: 3478149 (1969-11-01), Larson t al.
patent: 3510496 (1970-05-01), Aumuller et al.
patent: 3574741 (1971-04-01), Gould et al.
patent: 3660487 (1972-05-01), Larsen et al.
patent: 3758692 (1973-09-01), Larsen et al.
patent: 4087541 (1978-05-01), Eberlein et al.
patent: 4137318 (1979-01-01), Eberlein et al.
patent: 4378361 (1983-03-01), Schromm et al.
patent: 4505921 (1985-03-01), Beregi et al.
Arrowsmith John E.
Cross Peter E.
Thomas Geoffrey N.
Akers Lawrence C.
Ginsburg Paul H.
Pfizer Inc.
Richardson Peter C.
Rivers Diana G.
LandOfFree
Isoindolinone sulfonamide anti-arrhythmic agents does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Isoindolinone sulfonamide anti-arrhythmic agents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Isoindolinone sulfonamide anti-arrhythmic agents will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-243794