Use of substituted 5H-pyrido- and 5H-thiazolo(2',1':2,3)imidazo

Details Use of substituted 5H-pyrido- and 5H-thiazolo(2',1':2,3)imidazo Use of substituted 5H-pyrido- and 5H-thiazolo(2',1':2,3)imidazo

1986-12-19

1989-09-05

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514366, A61K 3144, A61K 31425

Patent

active

048639303

ABSTRACT:
5H-pyrido[2',1':2,3]imidazo[4,5-b]indoles of the formulae ##STR1## their pharmaceutically acceptable acid addition salts and the corresponding compounds bearing one or more halogens and/or lower-alkyl groups on the available ring carbon atoms are administered in cholinomimetic amounts to mammals with low acetylcholine or cholinergic activity to ameliorate the symptoms associated with that condition.

REFERENCES:
K. L. Davis et al., Cholinergic Drugs in Alzheimer's Disease, Editorials, The New England J. of Med., vol. 315, No. 20, pp. 1286-1287 (1986).
J. H. Growdon et al., Neurochemical Approaches to the Treatment of Senile Dementia, Psychopathology in the Aged, pp. 281-294 (1980).
P. Davies, Theoretical Treatment Posibilities for Dementia of the Alzheimer Type: The Cholinergic Hypythesis, Theoretical Treatment Strategies for the Development of an Effective Treatment for Senile Dementia, pp. 19-32 (1981).

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