Substituted 5-amino-4-hydroxyvaleryl derivatives

Details Substituted 5-amino-4-hydroxyvaleryl derivatives Substituted 5-amino-4-hydroxyvaleryl derivatives

1987-10-26

1989-09-05

Philipps, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 18, 530331, 530330, 530332, 530800, A61K 3743, C07K 506, C07K 508

Patent

active

048639036

ABSTRACT:
Compounds of the formula ##STR1## in which R.sub.1 represents hydrogen or acyl, X.sub.1 represents an optionally N-alkylated amino acid residue that is bonded N-terminally to R.sub.1 and C-terminally to X.sub.2, X.sub.2 represents an optionally N-alkylated amino acid residue that is bonded N-terminally to X.sub.1 and C-terminally to the group -NR.sub.2 -, R.sub.2 represents hydrogen or lower alkyl, R.sub.3 represents hydrogen, alkyl, cycloalkyl, aryl-lower alkyl or aryl, R.sub.4 represents hydroxy or etherified or esterified hydroxy, R.sub.5 represents alkyl, cycloalkyl, aryl-lower alkyl or aryl, and R.sub.6 represents free or substituted amino or substituted hydroxy, and salts of such compounds having salt-forming groups inhibit the blood pressure-increasing action of the enzyme renin and can be used as anti-hypertensives.

REFERENCES:
patent: 4198398 (1980-04-01), Hudson et al.
patent: 4304715 (1981-12-01), Hudson et al.
patent: 4424207 (1984-01-01), Szelke et al.
patent: 4470971 (1984-09-01), Boger et al.
patent: 4478826 (1984-10-01), Veber et al.
patent: 4479941 (1984-10-01), Veber et al.
patent: 4609643 (1986-09-01), Szelke et al.
patent: 4661473 (1987-04-01), Boger et al.
patent: 4727060 (1988-02-01), Buhlmayer et al.
Chemistry Letters, pp. 1041-1044, 1985, No. 7.
Szelke et al, Peptides: Structure and Function, Proceedings of the 8th American Peptide Symposium (1983) pp. 579-582.
Holladay et al Tetrahedron Letters, vol. 24, No. 41 pp. 4401-4403 (1983).
WO 84/03044 (1984).
Rich et al. Peptides: Structure and Function: Proceedings of the 8th American Peptide Symposium (1983) pp. 511-520.

Affiliated with

Also associated with

Rating

Substituted 5-amino-4-hydroxyvaleryl derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Substituted 5-amino-4-hydroxyvaleryl derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substituted 5-amino-4-hydroxyvaleryl derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-243513