Prodrugs for the improved delivery of halogen-containing glucoco

Details Prodrugs for the improved delivery of halogen-containing glucoco Prodrugs for the improved delivery of halogen-containing glucoco

1979-07-27

1981-07-21

Roberts, Elbert L.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

2602395, 26023955D, A61K 358

Patent

active

042799007

ABSTRACT:
Novel 3,2'-spiro(1',3'-thiazolidine) compounds which are transient prodrug forms of known 6- and/or 9-haloglucocorticosteroids are described. The subject prodrugs provide improved delivery of the prior art steroids for therapeutic purposes, particularly in alleviating inflammation, and can be prepared by known methods, for example, by reacting the corresponding 3-keto steroids with a thiazolidine forming reagent such as an L-cysteine alkyl ester.

REFERENCES:
patent: 3357972 (1967-12-01), Deason
patent: 4069322 (1978-01-01), Bodor et al.

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