In vivo inhibitors of cholesterol biosynthesis

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Virus or component thereof

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Details

424238, 2603971, 2603975, A01N 5700, A01N 4500

Patent

active

042798981

ABSTRACT:
Dialkyl esters of 5-carbo[etiocholane-3'.alpha.-7'.alpha., 12'.alpha.-trihydroxy-17'.beta.(1" methyl-4' butyl]oxy-4-hydroxy-4-methylpentyl-1-phosphonate and 5-carbohexadecyloxy-4-hydroxy-4-methylpentyl-1-phosphonate are shown to inhibit cholesterol biosynthesis in rat liver cells. Preparation of the active compounds is given.

REFERENCES:
patent: 4104285 (1978-08-01), Torres et al.
patent: 4107188 (1978-08-01), Torres et al.

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