Nucleic acid encoding novel human KDEL receptor

Details Nucleic acid encoding novel human KDEL receptor Nucleic acid encoding novel human KDEL receptor

1996-11-21

1998-10-20

Teng, Sally P.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4352523, 43525411, 4353201, 435325, 536 2431, 536 235, C12N 1512, C07K 14705

Patent

active

058245006

ABSTRACT:
The present invention provides a novel human KDEL receptor (NHKR) and polynucleotides which identify and encode NHKR. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding NHKR and a method for producing NHKR. The invention also provides for agonists, antibodies, or antagonists specifically binding NHKR, and their use, in the prevention and treatment of diseases associated with expression of NHKR. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding NHKR for the treatment of diseases associated with the expression of NHKR. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding NHKR.

REFERENCES:
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