Nucleic acid encoding human mevalonate kinase

Details Nucleic acid encoding human mevalonate kinase Nucleic acid encoding human mevalonate kinase

1990-02-06

1994-09-20

Moskowitz, Margaret

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 231, 536 235, 536 2351, 930240, C07H 1700

Patent

active

053490584

ABSTRACT:
Nucleic acid sequences, particularly DNA sequences, coding for all or a portion of human mevalonate kinase, expression vectors containing the DNA sequences, host cells containing the expression vectors, and methods for detecting the DNA sequences or the corresponding RNA sequences. The invention also concerns polypeptide molecules comprising all or a portion of human mevalonate kinase.

REFERENCES:
P.N.A.S. vol. 87(8), p. 2872 Tanaka et al. see abstract print out.
Talk Schedule for the 1988 Aspen Hepatic Cholesterol and Lipoprotein Conference, Aspen, Colo., Aug. 18-21, 1988 "Regulation and Molecular Cloning of mevalonate kinase from rat liver".
Tanaka, R. D., et al., "The Regulation and Molecular Cloning of Mevalonate Kinase from Rat Liver", Arteriosclerosis 9, 717a (1989) & Circulation 80 (1989).
Tanaka, R. D. et al., "Purification and Regulation of Mevalonate Kinase from Rat Liver", J. Biol. Chem. 265, 2391-2398 (1990).
Flint, A. P. F., "The Activity and Kinetic Properties of Mevalonate Kinase in Superovulated Rat Ovary", Biochem. J. 120, 145-150 (1970).
Beytia, E. et al., "Purification and Mechanism of Action of Hog Liver Mevalonic Kinase", J. Biol. Chem. 245, 5450-5458 (1970).
Tchen, T. T., "Mevalonic Kinase: Purification and Properties", J. Biol. Chem. 233, 1100-1103 (1958).
Garcia-Peregrin, E. et al., "Isolation of Two Fractions with Mevalonate Kinase Activity from Pinus Pinaster and Agave Americana", FEBS Letters 30, 18-19 (1973).
Markley, K. et al., "Mevalonic Kinase in Rabbit Liver", Biochemica et Biophysica Acta 47, 327-335 (1961).
Loomis, W. D. et al., "Biosynthesis of Terpenes III. Mevalonic Kinase from Higher Plants", Biochemica et Biophysica Acta, 67, 54-63 (1963).
Williamson, I. P. et al., "The Formation of 5-Phosphomevalonate by Mevalonate Kinase in Hevea brasilienisis Latex" Biochem. J. 96, 862-871 (1965).
Garcia-Martinez, J. et al., "Revista Espanola de Fisiologia, ", 261-266 (1982), Partial Purification and Properties of Mevalonate Kinase from Neonatal Chick Liver.
Potty, V. H. et al., "Mevalonate-Activating Enzymes in the Orange", Phytochemistry 9, 99-105 (1970).
Goodfellow, R. D. et al., "Mevalonate Kinase from the Larva of the Fleshfly, Sarcophaga Bullata", Insect Biochem. 1, 271-282 (1971).
Gray, J. C. et al., "Mevalonate Kinase in Green Leaves and Etiolated Cotyledons of the French Bean Phaseolus vulgaris", Biochem, J. 133, 335-347 (1973).
Cooper, C. Z. et al., "Mevalonic Acid Kinase in Euglena gracilis", Plant Physiol. 42, 515-519 (1967).
Ness, G. C. et al., "Influence of Mevalonate Kinase on Studies of the MgATP-Dependent Inactivator of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase.sup.1 ", Archives of Biochemistry and Biophysics 214, 705-713 (1982).
Lee, C. S. et al., "An Improved Purification Procedure, an Alternative Assay and Activation of Mevalonate Kinase by ATP", Biochimica et Biophysica Acta. 747, 215-224 (1983).
Dorsey, J. K. et al., "The Inhibition of Mevalonic Kinase by Geranyl and Farnesyl Pyrophosphates", J. Biol. Chem. 243, 4667-4670 (1968).
Levy, H. R. et al., "Mevalonic Kinase and Phosphomevalonic Kinase from Liver", Biochem. J. 75, 417-428 (1960).
Porter, J. W., "Mevalonate Kinase", Methods in Enzymol., vol. 110, p. 71 (1985).
Popjak, G., "Enzymes of Sterol Biosynthesis in Liver and Intermediates of Sterol Biosynthesis", Methods in Enzymology, vol. 15, 393-455 (1969).

Affiliated with

Also associated with

Rating

Nucleic acid encoding human mevalonate kinase does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Nucleic acid encoding human mevalonate kinase, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nucleic acid encoding human mevalonate kinase will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2429987