Nerve growth factor having altered receptor binding specificitie

Details Nerve growth factor having altered receptor binding specificitie Nerve growth factor having altered receptor binding specificitie

1992-03-06

1994-09-20

Hill, Jr., Robert J.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Hormones, e.g., prolactin, thymosin, growth factors, etc.

930120, C07K 1300

Patent

active

053490550

ABSTRACT:
A method of altering the receptor binding properties and the stability of neurotrophic factors is set forth. Mutant neurotrophic factors having altered receptor binding specificities are described. Specific embodiments include neurotrophic factors that bind trk receptors but do not bind to the low affinity NGF receptor.

REFERENCES:
Berg et al. Proc. Natl. Acad. Sci. 88:7106-7110 (1991).
Ibanez et al. EMBO J. 9(5):1477-1483 (1990).
Ibanez et al. EMBO J. 10(8):2105-2110 (1991).
Loeb et al. Cell 66:961-966 (1991).
Meier et al. EMBO J 5(7):1489-1493 (1986).

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