Method of promoting nitrogen retention in humans

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...

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514449, 426 2, 426531, A61K 3119, A61K 31335, A23L 103

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active

053489799

ABSTRACT:
Nitrogen retention in human subjects is promoted by administering .beta.-hydroxy-.beta.-methylbutyric acid (HMB). The amount of HMB administered is effective to conserve protein as determined by reduction in urinary nitrogen. The method can be used with patients having a negative nitrogen balance due to disease conditions, and also with normal elderly persons who are subject to protein loss. The HMB may be administered orally or by intravenous infusion.

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Chawla et al., J. Nutri. (1975) 105:798-803.
Boebel and Baker, J. Nutr. (1982) 112:1929-1939.
Tanaka et al., Biochim. Biosphys. Acta. 152:638-641 (1966).
Landass, Clin. Chim. Acta. 64:143-154 (1975).

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