Fibronectin-containing ophthalmic solution, method of preserving

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

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514912, A61K 3710

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active

053489390

ABSTRACT:
A stable and soluble multi-dose ophthalmic solution is disclosed. The solution contains fibronectin, an amino acid, a sugar, and a lower alkyl p-hydroxybenzoate. A method of treatment of ophthalmic wounds employing the ophthalmic solution, a process for preparing fibronectin for ophthalmic use, a method of lyophilizing an aqueous solution of fibronectin free of albumin, a method for inhibiting bacterial growth in an ophthalmic solution while preserving the cellular adhesion and wound healing activities of fibronectin, and a method of treatment of ophthalmic wounds administering a wound-healing accelerator solution are also disclosed.

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Nishida, T. et al., 102 Arch Opthamal., p. 455-456.
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Assouline, M. et al.,"Fibroblast Growth Factor Effects on Cornea Wound Healing in the Rabbit", Healing Processes in the Cornea, pp. 79-97 (Crosson and H. E. Kaufman, Eds.).
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