Naphthalene derivative

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai

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514381, 514522, 514533, 514534, 514561, 514562, 514563, 514602, 514603, 514618, 514619, 548253, 558415, 558416, 560 17, 562427, 562455, 564 84, 564 85, 564 86, 564 88, 564162, 564168, A61K 3124, C07C22900

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active

059454504

ABSTRACT:
##STR1## (wherein A is a hydrogen atom, a hydroxy group, a C.sub.7 -C.sub.11 aralkyloxy group, or an alkoxy group composed of an oxy group and a C.sub.1 -C.sub.12 aliphatic or alicyclic, saturated or unsaturated hydrocarbon group where the allyl may be substituted with a C.sub.6 -C.sub.10 allyloxy group; Q represents O, S, CH.sub.2, O--CH.sub.2, S--CH.sub.2, CO, or CHOR.sup.1 ; L represents CO, CR.sup.2 R.sup.3 CO, CH.sub.2 CH.sub.2 CO, or CH.dbd.CHCO; D represents a hydrogen atom, NO.sub.2, NH.sub.2, CO.sub.2 R.sup.4, or a group having the following ##STR2## (wherein G represents. a hydrogen atom, OH, SO.sub.2 NH.sub.2, CO.sub.2 R.sup.6, CN, or a tetrazol-5-yl group); E represents a hydrogen atom, OH, SO.sub.2 NH.sub.2, CO.sub.2 R.sup.5, CN, or a tetrazol-5-yl group; M represents a hydrogen atom, a C.sub.1 -C.sub.4 lower alkyl group, a nitro group, or a halogen atom; and R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are, independently each other, a hydrogen atom or a C.sub.1 -C.sub.4 lower alkyl group);

REFERENCES:
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Department of Bacteriology, Department of Opthamology, School of Medicine, Iwate Medical University, Japan Opthalmol. Soc. 1993 pp. 792-799 Kazuhiro Takahashi, "Participation of Procoagulant Activity of Cultured Rabbit Lens Epithelial Cells in Fibrin Formulation".
European Journal of Medicinal Chemistry, vol. 26, Mar. 1991, pp. 159-166, Murray, et al. Novel 6-oxo-6-naphthylhexaonic acid derivatives with anti-inflammatory and 5-lipoxygenase Inhibitory Activity.
Helvetica Chimica Acta, vol. 39, (1956), pp. 1892-1899, Chardonnens et al. Sur l'aptitude reactionnelle du groupement methylique XIV), Influence des groupements .alpha.- et .beta.-naphtoyles.
Biochemical and Biophysical Research Communications, vol. 119, Feb. 29, 1984, Crutchley, pp. 179-184 "Effects of Inhibitors of Arachidonic Acid Metabolism on Thromboplastin Activity in Human Monocytes".
Chardonnens et.al., Helv. Chim. Acta, vol. XXXIX, No. 224, pp. 1892-1899, 1956.
International Search Report.

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