Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-06-04
1999-08-31
Cook, Rebecca
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514277, 514336, 514342, 514343, 514880, A61K 3140, A61K 31435
Patent
active
059454415
ABSTRACT:
This invention relates to methods of treating hair loss, through hair revitalization and germination, by administering non-immunosuppresive pyrrolidine carboxylate compounds.
REFERENCES:
patent: 4996193 (1991-02-01), Hewitt et al.
patent: 5189042 (1993-02-01), Goulet et al.
patent: 5192773 (1993-03-01), Armistead et al.
patent: 5208241 (1993-05-01), Ok et al.
patent: 5258389 (1993-11-01), Goulet et al.
patent: 5284826 (1994-02-01), Eberle
patent: 5284840 (1994-02-01), Rupprecht et al.
patent: 5284877 (1994-02-01), Organ et al.
patent: 5292747 (1994-03-01), Davis et al.
patent: 5342625 (1994-08-01), Hauer et al.
patent: 5385918 (1995-01-01), Connell et al.
patent: 5457111 (1995-10-01), Luly et al.
patent: 5470878 (1995-11-01), Michnick et al.
patent: 5506228 (1996-04-01), Norton et al.
patent: 5532248 (1996-07-01), Goulet et al
patent: 5614547 (1997-03-01), Hamilton et al.
Birkenshaw, T.N. et al., "Synthetic FKBP12 Ligands. Design and Synthesis of Pyranose Replacements," Bioorganic & Medicinal Chemistry Letters, (1994) 4:21, 2501-2506.
Caffrey, M.V. et al., "Synthesis and Evaluation of Dual Domain Macrocyclic FKBP12 Ligands," Bioorganic & Medicinal Chemistry Letters, (1994) 4:21, 2507-2510.
Hauske, J.R. et al. "Design and Synthesis of Novel FKBP Inhibitors," J. of Medicinal Chemistry, (1992) 35, 4284-4296.
Holt, D.A. et al., "Design, Synthesis, and Kinetic Evaluation of High-Affinity FKBP Ligands and the X-ray Crystal Structures of Their Complexes with FKBP12," J. Am. Chem. Soc., (1993) 115, 9925-9938.
Holt, D.A. et al., "Structure-Activity Studies of Synthetic FKBP Ligands as Peptidyl-prolyl Isomers Inhibitors," Bioorganic & Medicinal Chemistry Letters, (1994) 4:2, 315-320.
Holt, D.A. et al., "Structure-Activity Studies of Nonmacrocyclic Rapamycin Derivatives," Bioorganic & Medicinal Chemistry Letter, (1993) 3:10, 1977-1980.
Luengo, J.I. et al., "Synthesis and Structure-Activity Relationships of Macrocyclic FKBP Ligands," Bioorganic & Medicinal Chemistry Letters, (1994) 4:2, 321-324.
Snyder, S.H. et al., "Immunophilins and the Nervous System," Nature Medicine, (1995) 1:1, 32-37.
Teague, S.J. et al., "Synthesis and Study of a Non-Macrocyclic FK506 Derivative," Bioorganic & Medicinal Chemistry Letters, (1994) 4:13, 1581-1584.
Teague, S.J. et al., "The Affinity of the Excised Binding Domain of FK-506 for the Immunophilin FKBP12," Bioorganic & Medicinal Chemistry Letters, (1993) 3:10, 1947-1950.
Wang, G.T. et al., "Synthesis and FKBP Binding of Small Molecule Mimics of the Tricarbonyl Region of FK506," Bioorganic and Medicinal Chemistry Letters, (1994) 4:9, 1161-1166.
Yamashita, D.S. et al., "Design, Synthesis and Evaluation of Dual Domain FKBP Ligands," Bioorganic & Medicinal Chemistry, (1994) 4:2, 325-328.
Iwabuchi, T. et al., "Effects of immunosuppressive peptidyl-prolyl cis-trans isomerase (PPIase inhibitors, cyclosporin A, FK506, ascomycin and rapamycin, on hair growth initiation in mouse: immunosuppression is not required for hair growth," J. of Deramatol. Sci., (1995) 9:1, 64-69.
Yamamoto, S. et al., "Stimulation of hair growth by topical application of FK506, a potent immunosuppressive agent," J. Invest. Dermatol, (1994) 102:2, 160-164.
Jiang, H. et al., "Induction of anagen in telogen mouse skin by topical application of FK506, a potent immunosuppressant," J. Invest. Dermatol., (1995) 104:4, 523-525.
CA126:272710, Steiner et al, 1997.
Hamilton Gregory S.
Steiner Joseph P.
Cook Rebecca
GPI Nil Holdings Inc.
Juneau Todd L.
Nath Gary M.
LandOfFree
Pyrrolidine carboxylate hair revitalizing agents does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Pyrrolidine carboxylate hair revitalizing agents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pyrrolidine carboxylate hair revitalizing agents will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2426602