Peptide analogues of the 65KD isoform of human glutamic acid dec

Details Peptide analogues of the 65KD isoform of human glutamic acid dec Peptide analogues of the 65KD isoform of human glutamic acid dec

1995-06-23

1999-08-31

Mertz, Prema

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530323, 530326, 530327, 530329, A61K 3843

Patent

active

059454016

ABSTRACT:
Peptides and peptide analogues of the 65 kD isoform of human glutamic acid decarboxylase are provided for use in the treatment and prevention of diabetes. Peptide analogues contain generally from one to three amino acid alterations. Peptides and analogues may be used to diagnose diabetes and detect a predisposition to diabetes.

REFERENCES:
patent: 5041380 (1991-08-01), Ruoslahti et al.
patent: 5674978 (1997-10-01), Tobin et al.
Guery et al. Critical Rev. Immunol. 13, 195-206, 1993.
Chicz et al. Immunol. Today 15, 155-160, 1994.
Evavold et al. Immunol. Today 14, 602-609, 1993.
Schon et al. J. Bacteriol. 175, 2465-2469, 1993.
Chen et al., "Responses of NOD Congenic Mice to a Glutamic Acid Decarboxylase-derived Peptide," Journal of Autoimmunity 7: 635-641, 1994.
Karlsen et al., "Cloning and primary structure of a human islet isoform of glutamic acid decarboxylase from chromosome 10," Proc. Natl. Acad. Sci. USA 88: 8337-8341, 1991.
Kaufman et al., "Spontaneous loss of T-cell tolerance to glutamic acid decarbaoxylase in murine insulin-dependent diabetes," Nature 366: 69-72, 1993.
Li et al., "Indentification of Autoantibody Epitopes of Glutamic Acid Decarboxylase in Stiff-Man Syndrome Patients," Journal of Immunology 152(2): 930-934, 1994.
Lohmann et al., "Immunodominant epitopes of glutamic acid decarboxylase 65 and 67 in insulin-dependent diabetes mellitus,"The Lancet343(8913): 1607-1608, 1994.
Quinn and Sercarz, "T Cells with Multiple Fine Specificities are Used by Non-obese Diabetic (NOD) Mice in the Response to GAD (524-543),"Journal of Autoimmunity9: 365-370, 1996.
Sai et al., "Immunization of non-obese diabetic (NOD) mice with glutamic acid decarboxylase-derived peptide 524-543 reduces cyclophosphamide-accelerated diabetes," Clin. Exp. Immunol 105: 330-337, 1996.

Affiliated with

Also associated with

Rating

Peptide analogues of the 65KD isoform of human glutamic acid dec does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Peptide analogues of the 65KD isoform of human glutamic acid dec, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Peptide analogues of the 65KD isoform of human glutamic acid dec will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2426542