Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1998-04-03
1999-08-31
Feisee, Lila
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
536 231, 536 243, 4353201, 435325, 4352523, 4351723, C07H 2104, C12N 1512, C12N 1563
Patent
active
059453087
ABSTRACT:
The invention provides a human oxidized LDL receptor (HOLR) and polynucleotides which identify and encode HOLR. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of HOLR.
REFERENCES:
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Hajjar, D.P. and M.E. Haberland, "Lipoprotein Trafficking in Vascular Cells", J. Biol. Chem., 272: 22975-22978 (1997).
Sawamura, T. et al., (Direct Submission), GenBank Sequence Database (Accession AB010710 D89050), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894, (GI 2828355; GI 1902984).
Sawamura, T. et al., (Direct Submission), GenBank Sequence Database (Accession D89049), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894, (GI 1902981; GI 1902982).
Kume, N. et al., "Receptors for modified low-density lipoproteins on human endothelial cells: different recognition for acetylated low-density lipoprotein and oxidized low-density lipoprotein", Biochim. Biophys. Acta, 1090: 63-67 (1991).
Corley Neil C.
Patterson Chandra
Sather Susan
Tang Y. Tom
Basi Nirmal S.
Feisee Lila
Incyte Pharmaceuticals Inc.
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