Antisense modulation of RhoA expression

Details Antisense modulation of RhoA expression Antisense modulation of RhoA expression

1998-09-18

1999-08-31

Elliott, George C.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 911, 435325, 435366, 536 231, 536 245, C12Q 168, C12N 1585, C07H 2104

Patent

active

059452900

ABSTRACT:
Antisense compounds, compositions and methods are provided for modulating the expression of RhoA. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding RhoA. Methods of using these compounds for modulation of RhoA expression and for treatment of diseases associated with expression of RhoA are provided.

REFERENCES:
del Peso et al., Rho proteins induce metastatic properties in vivo, Oncogene, 1997, 15:3047-3057.
Donovan et al., Thrombin induces apoptosis in cultured neurons and astrocytes via a pathway requiring tyrosine kinase and RhoA activities, J. Neurosci., 1997, 17:5316-5326.
Hall, Rho GTPases and the actin cytoskeleton, Science, 1998, 279:509-514.
Khosravi-Far et al., Increasing complexity of Ras signal transduction: involvement of Rho family proteins, Adv. Cancer Res., 1998, 72:57-107.
Ren et al., Modulation of small G protein isoprenylation by anticancer monoterpenes in in situ mammary gland epithelial cells, Carcinogenesis, 1998, 19:827-832.
Ridley, The GTP-binding protein Rho, Int. J. Biochem. Cell Biol., 1997, 29:1225-1229.

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