Imidazole derivatives, pharmaceutical compositions and use

Details Imidazole derivatives, pharmaceutical compositions and use Imidazole derivatives, pharmaceutical compositions and use

1990-10-09

1992-05-12

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514326, 514397, 514400, 540603, 546210, 548336, 548342, C07D22304, C07D23364, A61K 3155, A61K 31415

Patent

active

051128195

ABSTRACT:
Certain novel imidazole derivatives N-substituted by a vinyl group itself carrying a mevalonic acid derivative or corresponding lactone are inhibitors of HMG-CoA reductase and are useful for lowering blood plasma cholesterol levels.
The compounds are of general formula (I): ##STR1## in which one of the groups R.sup.1 and R.sup.2 represents a C.sub.1-6 alkyl group optionally substituted by one to three halogen atoms and the other represents a phenyl ring optionally substituted by one to five substituents selected from halogen atoms and hydroxyl, C.sub.1-3 alkyl, C.sub.1-3 alkoxy, S(O).sub.n C.sub.1-3 alkyl, (CH.sub.2).sub.m NR.sup.a R.sup.b, (CH.sub.2).sub.m NR.sup.c COR.sup.d and trifluoromethyl groups;

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patent: 4870199 (1989-09-01), Chen et al.
patent: 4927851 (1990-05-01), Damon, II et al.
patent: 4946841 (1990-08-01), Baader et al.
patent: 5013749 (1991-05-01), Watson et al.

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