Screening for anti-adhesin antibiotics by employing photoinduced

Details Screening for anti-adhesin antibiotics by employing photoinduced Screening for anti-adhesin antibiotics by employing photoinduced

1990-02-23

1992-05-12

Wax, Robert A.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving viable micro-organism

435124, 549267, C12Q 118, C12P 1708, C07D32104

Patent

active

051127423

ABSTRACT:
The present invention relates to the method of screening for antibiotics employing a cyanobacterium, Nostoc muscorum A. The cyanobacterium is photoinduced under specified growing conditions to enable the cyanobacterium to be employed for screening of chemicals or organisms that exhibit anti-adhesin properties. These anti-adhesin properties are characterized by zones of interference in the photoinduced lawns of the cyanobacterium.

REFERENCES:
N. Lazaroff, "Chemical inhibition of harmogonial motility and aggregation in a nitrogen fixing cyanobacterium" Abst. First Int. Phycological Congress, St. Johns, Newfoundland (1982).
N. Lazaroff, E. DiBlasio, & C. Tannenbaum, "A comparative study of photoinduced nostocacean development" Abst. Phycol. Soc. Meeting 1984, Ft. Collins, Colo. p. 23.
N. Lazaroff, "Hotomorphogenesis and nostocacean development" pp. 279-319, The Biology of Blue-Green Algae, Blackwell Scientific, Oxford 1973.
N. Lazaroff, "Experimental control of nostocacean development" Symposium on Taxonomy and Biology of Blue-green algae, Madras University Press, pp. 521-544 (1972).
N. Lazaroff, "Control of hormogonial release and motility in a filamentous blue-green algae" Abst. of XI Int. Botan. Cong., Seattle 1969 p. 123.
N. Lazaroff & P. M. Jackson, "Hormogonial aggregation and colonial morphogenesis of Nostoc Muscorum" Abst. A.S.L.O. & Phycol. Soc. p. 73, (1986).
N. Lazaroff & W. Vishniac, "The effect of light on the development cycle of Nostoc muscorum A filamentous blue-green algae" Journal General Microbiology 25 pp. 365-374 (1961).

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