Spheroidal silica

Details Spheroidal silica Spheroidal silica

1990-05-23

1992-05-12

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

423335, 5142262, A61K 900

Patent

active

051126125

ABSTRACT:
Porous spheroidal silica having a particle size in the range 1 to 400 microns, axial ratios of 1:1 to 1:12 has up to 50% by weight of the SiO.sub.2 of included material, such as for example perfumes, flavoring materials, pigments, germicides, bactericides, fungicides, bleaching agents, skin benefit agents, therapeutic agents, dispersed in the silica as particles or droplets in the size range 0.01 to 10 .mu.m. The spheroids can be made by mixing together an aqueous, stabilized silica sol containing dispersed therein up to 50% by weight of the silica of an included material and an aqueous solution of a non-adsorbing polymer to form a phase separated system comprising silica droplets containing included material in a polymer-rich continuous phase and condensing the silica sol to aggregate the droplets to form silica spheroids containing the dispersed included material. The included material can be released in use by e.g. wetting, attrition, dissolution, pH change, heating.

REFERENCES:
patent: 4169069 (1979-09-01), Unger
patent: 4487657 (1984-12-01), Gomez
patent: 4778667 (1988-10-01), Garvey

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