Liposome compositions of anthracycline derivatives

Details Liposome compositions of anthracycline derivatives Liposome compositions of anthracycline derivatives

1987-05-19

1989-09-05

Lovering, Richard D.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

264 43, 264 46, 4284022, 436829, 514 34, 514908, A61K 3722, A61K 966, A61K 4505, B01J 1302

Patent

active

048637394

ABSTRACT:
Disclosed are liposomal antitumor compositions having improved pharmacological characteristics. Liposomes described herein are formed through the incorporation of a particular class of anthracyclines, the 4-demethoxy-3'-desamino-2'-iodo analogs, shown to have extremely high incorporatio efficiencies of greater than 95%. These liposomes demonstrate an improved antitumor efficacy, with much reduced toxicity, against accepted tumor models, and further exhibit excellent stability upon storage, for example, in the form of a dried powder.

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