Preparation of alkyl N-maleylphenylalanate

Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acid esters

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562450, C07C 67313

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active

047090758

ABSTRACT:
Alkyl N-maleylphenylalanate is prepared by reacting the starting material alkyl L-phenylalanate and maleic anhydride in aqueous solution at a pH of at most 7.5. The reaction products can be isomerized with dipolar aprotic solvents into the corresponding fumaric acid monoamides and thus can be used as an intermediate in the preparation of alkyl .alpha.-L-aspartyl-L-phenylalanate.

REFERENCES:
patent: 3901871 (1975-08-01), Anderson
patent: 4507231 (1985-03-01), Gourbault
patent: 4539147 (1985-09-01), Filippini et al.

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