Acylmercaptoalkanoyl and mercaptoalkanoyl spiro compounds

Details Acylmercaptoalkanoyl and mercaptoalkanoyl spiro compounds Acylmercaptoalkanoyl and mercaptoalkanoyl spiro compounds

1983-05-09

1987-11-24

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546 15, C07D491113, C07D49510, A61K 3140, A61K 3144

Patent

active

047090464

ABSTRACT:
Spiro compounds of the formula ##STR1## wherein X is oxygen or sulfur. These compounds possess antgiotensin converting enzyme inhibition activity and are thus useful as anti-hypertension agents.

REFERENCES:
patent: 4105776 (1978-09-01), Ondetti et al.
patent: 4311697 (1982-01-01), Krapcho
patent: 4384123 (1983-05-01), Petrillo, Jr.
Brunner et al., "Oral Angiotensin-Converting Enzyme Inhibitor . . . ", Ann. of Int. Med., vol. 90 pp. 19-23 (1979).
Aldigier et al., "Dose Dependency of Captopril . . . , " J. Cardiovasc. Pharmacol., vol. 3, No, 6, 1229-1235 (1981).

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