Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1985-06-07
1987-11-24
Phillips, Delbert R.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
C07K 1300
Patent
active
047090170
ABSTRACT:
Diphtheria toxin, fragment A, which has been modified by the deletion of Glu-148 or the substitutions of Glu-148 with Asp is catalytically inactive and immunologically cross-reactive with naturally occurring diphtheria toxin, fragment A. The modified diphtheria toxin is compounded with a pharmacologically suitable vehicle to form a vaccine that is innoculated into a mammal to generate immunological protection against diphtheria toxin. The modified diphtheria toxin is produced by a cell that includes a vector having DNA encoding the non-toxic protein and regulatory DNA capable of effecting its expression.
REFERENCES:
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Carroll Stephen F.
Collier R. John
Phillips Delbert R.
President and Fellows of Harvard College
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