Combination therapy using immunotoxins with interleukin-2

Details Combination therapy using immunotoxins with interleukin-2 Combination therapy using immunotoxins with interleukin-2

Filed on

1987-12-09

Date issued

1989-09-05

Examiner

Schain, Howard E.

Patent Class

Drug, bio-affecting and body treating compositions

SubClass

Lymphokine

SubSubClass

Interleukin

Other Related Categories

424 851, 424 858, 424 8591, 514 2, 514 8, 514 21, 514885, 530351, 530389, 530391, A61K 3702

Type

Patent

Status

active

Patent number

048637262

Description

ABSTRACT:
Anti-tumor activity in humans can be augmented by administering to the mammalian host a pharmacologically effective amount of mammalian IL-2 and at least one immunotoxin that binds selectively to human tumor cells. The IL-2 and immunotoxin are preferably administered separately to the host. The composition is useful for prophylactic or therapeutic treatment of such cancers as ovarian and breast cancer.

REFERENCES:
patent: 4604377 (1986-08-01), Fernandes et al.
Dr. Rosenstein et al., J. Immunol. (1986), 137:1735-1742.
Shaw et al., Cell Immunol. (1985), 91:193-200.
Shaw et al., Cell Immunol. (1985), 90:547-554.
Nonomura et al., Hepatology (1984), 4:1087.
Kimber et al., J. Clin. Lab. Immunol. (1984), 15:77-84.
Lotze et al., J. Immunol. (1985), 135:2865.

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