Photo-labile compounds, their synthesis and use as fluorophores

Details Photo-labile compounds, their synthesis and use as fluorophores Photo-labile compounds, their synthesis and use as fluorophores

1993-05-06

1995-07-18

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549223, C07D31182

Patent

active

054342724

ABSTRACT:
##STR1## Compounds of formulae (I), (II) wherein X is an optionally substituted benzyl group which carries an NO.sub.2 group in the ortho-position, Z is a group of formula .alpha. or .beta., R, R' and Y are each optionally substituted groups, R" is hydrogen or alkyl, m and n are each integers of from 1 to 6, and q is an integer of from 1 to 20, and salts thereof. These protected or caged organic compounds, based on the dyes fluorescein (I) and rhodamine (II), can be introduced into biological systems and there released by means of light radiation. They are suitable, for example, for use in the labelling of proteins or lipophilic structures. Processes for the preparation of the compounds are also described.

REFERENCES:
J. F. Burd et al., Analytical Biochemistry, 77(1), 1977, pp. 56-57.
G. A. Kraft et al., Journal of the American Chemical Society, 110(1), 1988, pp. 301-303.

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