Phenylimidazolidines

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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5483014, A61K 31415

Patent

active

054341760

ABSTRACT:
A compound selected from the group consisting of compounds of the formula ##STR1## wherein R.sub.1 and R.sub.2 are individually selected from the group consisting of --CN, --NO.sub.2, halogen, --CF.sub.3, free carboxy, salified carboxy, and carboxy esterified with lower alkyl; -A-B- is selected from the group consisting of ##STR2## and X, R.sub.3, R.sub.4 and R.sub.5 are defined as in the specification and their non-toxic, pharmaceutically acceptable acid addition salts having anti-androgenic activity.

REFERENCES:
patent: 379038 (1975-01-01), Magnani
patent: 4473393 (1984-09-01), Nagpal
patent: 4753957 (1988-06-01), Chan
patent: 4944791 (1990-07-01), Schroder et al.
patent: 5084472 (1992-01-01), Moguilewsky et al.
Chemical Abstracts vol. 114, No. 119, Abst. No. 185374 (1991).
Kruger et al., Arch. Pharm 311, pp. 39-47 (1978).
CA. 81, No. 7, Aug. 19, 1984.

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