Cosmetic or pharmaceutical compositions containing, as active in

Details Cosmetic or pharmaceutical compositions containing, as active in Cosmetic or pharmaceutical compositions containing, as active in

1996-09-18

1998-10-20

Venkat, Jyothsan

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Cosmetic, antiperspirant, dentifrice

424 61, 424701, 514455, 514844, 514846, 514937, 514944, A61K 748

Patent

active

058243208

DESCRIPTION:

BRIEF SUMMARY
This application is a 371 of PCT/FR95/01552 filed Nov. 23, 1995.


FIELD OF THE INVENTION

The invention relates to cosmetic or pharmaceutical compositions containing, as active ingredient, mangiferine (or its derivatives) of natural origin or obtained by chemical, enzymatic or biotechnological synthesis, as well as to compositions containing, as active ingredient, a mangiferine-containing plant extract, in particular an Aphloia or Mangifera leaf extract.
These compositions can be used especially to protect the skin against ultraviolet radiation and skin ageing and to enhance its structural quality.


BACKGROUND OF THE INVENTION

Mangiferine is a C-glucoside of 1,3,6,7-tetrahydroxy xanthone. It is also called aphloiol (Billet and al., 1965). This molecule, as well as its derivatives (methylated, O-glucosyl or isomangiferine derivatives), are present naturally in a number of plants, but it is mangiferine that is the most widely distributed C-glucoside xanthone (Hostettmann, 1977), and more particularly among the angiosperms.
It has the chemical structure below: ##STR1##
where R.sub.1 .dbd.R.sub.3 .dbd.R.sub.6 .dbd.R.sub.7 .dbd.OH and R.sub.4 .dbd.R.sub.5 .dbd.R.sub.8 .dbd.H.
Isomangiferine, which has the structure below: ##STR2## where R.sub.1 .dbd.R.sub.3 .dbd.R.sub.6 .dbd.R.sub.7 .dbd.OH and R.sub.2 .dbd.R.sub.5 .dbd.R.sub.8 .dbd.H, also exists naturally. Its derivatives of natural origin can have O-methyl (--OCH.sub.3) or glucosyl (--C.sub.6 H.sub.11 O.sub.6) groups at the R.sub.1, R.sub.3, R.sub.6 or R.sub.7 positions.
All the compounds formed by mangiferine and its derivatives correspond to the following general formula (I): ##STR3## where R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7 are selected from --H, --OH, --OCH.sub.3 and a glucosyl radical.
The compounds of formula I can be obtained by various means:
1) extraction from plant materials. Mangiferine and its derivatives are present naturally in various plants, including in particular the species indicated in the following table:


__________________________________________________________________________ CLASS SUBCLASS ORDER FAMILY SPECIES __________________________________________________________________________ Filices Leptosporangiatae Filicales Polypodiaceae Athyrium mesosorum Dicotyledoneae Archichlamydeae Guttiferales Guttiferae Hypericum acutum H. chinense H. humifusum H. montanum H. nummularium H. pulchrum Rosales Leguminosae Hedysarum obscurum Rutales Malphighiaceae Hiptage madablota Sapindales Anacardiaceae Mangifera indica Celastrales Hippocrateaceae Salacea prunoides Violales Flacourtiaceae Flacourtia indica Aphloia theaeformis A. madagascariensis Sympetalae Ebenales Sapotaceae Madhuca utilis Tubiflorae Convolvulacea Cuscuta reflexa Monocotyledoneae Liliiflorae Liliceae Anemarrhena rhizoma Smilax glycyphylla Iridaceae All spp. of pogoniris section Iris pseudacorus Iris dichotoma Belamcanda chinensis Crocus aureus Graminales Gramineae Cymbopogon afronardus __________________________________________________________________________
The species Aphloia and Mangifera are plants whose leaves are high in mangiferine.
Aphloia is a shrub which is completely glabrous, 3 to 4 m high, native to the East coast of Madagascar and the neighbouring islands (Reunion, Mauritius, Seychelles, Comoro). The alternate leaves are simple, lanceolate, dentate to a greater or lesser extent along the edges except at the base and are not stipulate.
The solitary hermaphrodite flowers, in the form of pauciflores cymes, are apetalous. They possess 4 to 6 imbricated sepals; the innermost are petaloid.
The fruits are berries which are white when mature.
The leaves of this plant are known for their diuretic, veinotonic and cicatrizant properties which have caused them to be used as infusion in traditional medicine.
Mangifera, and in particular Mangifera indica, belongs to the Anacardiaceae family. The genous mangifera is characterized by the follo

REFERENCES:
patent: 4217341 (1980-08-01), Suddick et al.
S. Guha et al., "Activation of Peritoneal Macrophages by Mangiferin, a Naturally Occurring Xanthone", Phytotherapy Research, vol. 7, No. 2, 1993, pp. 107-110.
T. Sato et al., "Mechanism of Antioxidant Action of Pueraria Glycoside (PG)--1 (an Isoflavonoid) and Mangiferin (a Xanthonoid)", Chemical Pharmaceutical Bull., vol. 40, No. 3, 1992, pp. 721-724.

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