Process for resolution and racemization of amines with acidic .a

Details Process for resolution and racemization of amines with acidic .a Process for resolution and racemization of amines with acidic .a

1989-01-19

1989-08-22

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

540570, 564302, 564303, 564304, C07B 5500, C07D24300

Patent

active

048597716

ABSTRACT:
An economical, one-pot process for resolution-racemization of primary amines with .alpha.-hydrogens via selective crystallization of diastereomeric chiral sulfonic acid salts and the subsequent in situ racemization of the other enantiomer by the catalytic addition of aromatic aldehydes, and a key process intermediate thereof.

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Clark et al., "Jour. Chem. Soc., Perkin I", pp. 475-481, (1976).
"The Merck Index", 10th Ed., p. 239, Section No. 1712, (1983).
Stinson, S. C., Chem. Eng. News, Issue of Oct. 19, 1987, pp. 30-33.

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