Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector
Patent
1995-06-07
1998-10-20
Housel, James C.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
4242091, 4242111, 4242121, 4242451, 514167, A61K 3900, A61K 39145, A61K 39155, A61K 3907
Patent
active
058243135
ABSTRACT:
The invention relates to a vaccine which comprises an antigen and a lymphoid organ modifying agent. Suitable lymphoid organ modifying agents include, but are not limited to, 1,25-dihydroxy Vitamin D.sub.3, biologically active Vitamin D.sub.3 derivatives which are capable of activating the intracellular Vitamin D.sub.3 receptor, all trans-retinoic acid, retinoic acid derivatives, retinol, retinol derivatives and glucocorticoid. The vaccine composition may further comprise an immune response augmenting agent. The immune response augmenting agent enhances T cell lymphokine production. Suitable immune response augmenting agents include, but are not limited to, dehydroepiandrosterone (DHEA), DHEA congeners and DHEA-derivatives. The invention also relates to a method for inducing an antigen-specific mucosal immune response in a subject vertebrate animal which comprises administering a vaccine which comprises an antigen and a lymphoid organ modifying agent to a site which drains into a peripheral lymph compartment. Alternatively, the method comprises separately administering the lymphoid organ modifying agent and a vaccine containing an antigen to the same site. The method may further comprise additionally administering an immune response augmenting agent which enhances T cell lymphokine production. The immune response augmenting agent may be administered sequentially or contemporaneously with the lymphoid organ modifying agent.
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Araneo Barbara A.
Daynes Raymond A.
Housel James C.
Swartz Rodney P.
University of Utah Research Foundation
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