Alkyl-substituted benzoxazinorifamycin derivative, process for p

Details Alkyl-substituted benzoxazinorifamycin derivative, process for p Alkyl-substituted benzoxazinorifamycin derivative, process for p

1987-07-13

1989-08-22

Bond, Robert T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

540457, A61K 31535, C07D49818

Patent

active

048596612

ABSTRACT:
A novel rifamycin derivative having the formula (I): ##STR1## wherein X.sup.1 is an alkyl group with 1 to 6 carbon atoms or a cycloalkyl group with 3 to 8 carbon atoms; X.sup.2 is a hydrogen atom or an alkyl group with 1 to 4 carbon atoms; R.sup.1 is hydrogen atom or acetyl group; A is a group represented by the formula: ##STR2## wherein R.sup.2 is an alkyl group with 1 to 4 carbon atoms or an alkoxyalkyl group with 2 to 6 carbon atoms and R.sup.3 is an alkyl group with 1 to 6 carbon atoms or an alkoxyalkyl group with 2 to 6 carbon atoms, or a group represented by the formula ##STR3## wherein ##STR4## is a 3 to 9 membered cyclic amino group with 2 to 8 carbon atoms, R.sup.4 is a hydrogen atom or an alkyl group having 1 to 4 carbon atoms, or salts thereof, a process for preparing the same and antibacterial agents containing the same as an effective ingredient.
The rifamycin derivative of the present invention having the formula (I) shows a strong antibacterial activity against the Gram-positive bacteria and the acid-fast bacteria.

REFERENCES:
patent: 4690919 (1987-09-01), Yamane et al.
Chemical Abstracts, vol. 68, No. 23, Jun. 3, 1968, p. 10107, Abstract No. 104800f.
Chemical Abstracts, vol. 68, Subject Index E-O, Jan.-Jun. 1968, p. 13835, Column 3, formula I.

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