Amino-substituted pyrimidines, derivatives and methods of use th

Details Amino-substituted pyrimidines, derivatives and methods of use th Amino-substituted pyrimidines, derivatives and methods of use th

1991-01-11

1992-05-19

Friedman, S. J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61K 31505

Patent

active

051149435

ABSTRACT:
The present invention relates to compositions and methods for inhibiting nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises an agent capable of inhibiting the formation of advanced glycosylation end products of target proteins by reacting with the carbonyl moiety of the early glycosylation product of such target proteins formed by their initial glycosylation. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated.

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