Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving viable micro-organism
Patent
1990-10-23
1992-05-19
Lilling, Herbert J.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving viable micro-organism
435119, 435180, 435245, 4352535, 4352536, 435886, C12Q 104, C12N 136, C12P 1718
Patent
active
051148463
ABSTRACT:
A method for selecting hyper-producing strains of streptovaricin C by culturing streptomyces spectabilis and separating the asporogenous colonies. The asporogenous colonies are then separately cultured and tested for streptovaricin productivity. Those colonies having the highest productivity may then be easily selected.
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K. L. Rinehart Jr., et ., "Relative biological activities of individual streptovaricins and streptovaricin acetates," Biochemistry, vol. 13, No. 5, pp. 861-867 (1974).
K. Sasaki, et al., "Chemical modification of streptovaricins C," J. Antibiotics, vol. 29, No. 2, pp. 147-154 (Feb. 1976).
S. Ito, et al., "Selective killing of human T cell lymphotropic virus type I-transformed cell lines by a damavaricin F.sub.c derivative," J. Antibiotics, vol. 42, No. 5, pp. 779-787 (May 1989).
Wang, "Annuals New York Academy of Sciences", V431, 1483, pp. 313-321 (1983).
Armentrout Richard W.
Inoue Kaname
Yamazaki Motohide
Lilling Herbert J.
Shin-Etsu Bio, Inc.
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